Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-9-30
pubmed:abstractText
We describe an in vitro system in which positive selection of developing T cells takes place on defined stromal cell preparations, which include major histocompatibility complex class II+ epithelial cells but exclude cells of bone marrow origin. In this system, maturation of double-positive T cell receptor negative (TCR-), CD4+8+ thymocytes into single-positive TCR+, CD4+ and CD8+ cells takes place together with the development of functional competence. As in vivo, this maturation is associated with the upregulation of TCR levels as cells progress from double-positive to single-positive status. We also show that class II+ epithelial cells in these cultures are less efficient than dendritic cells in mediating the deletion (negative selection) of V beta 8+ cells by the superantigen staphylococcal enterotoxin B. For the first time, this approach provides a model in which the cellular interactions involved in both positive and negative selection can be studied under controlled in vitro conditions.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-1668372, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-1828695, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-1888430, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-1900074, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-1900076, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2138780, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2138784, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2147650, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2149067, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2151796, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2188673, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2222760, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2476238, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2505933, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2511629, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2521300, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2532142, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2571938, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2591368, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-2788823, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-3678361, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-4007044, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-6362104, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-6389154, http://linkedlifedata.com/resource/pubmed/commentcorrection/1512547-7308288
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
176
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
845-53
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Studies on T cell maturation on defined thymic stromal cell populations in vitro.
pubmed:affiliation
Department of Anatomy, Medical School, University of Birmingham, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't