| pubmed-article:1512541 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1512541 | lifeskim:mentions | umls-concept:C0004827 | lld:lifeskim |
| pubmed-article:1512541 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:1512541 | lifeskim:mentions | umls-concept:C2350701 | lld:lifeskim |
| pubmed-article:1512541 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:1512541 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:1512541 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1512541 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1512541 | pubmed:dateCreated | 1992-9-30 | lld:pubmed |
| pubmed-article:1512541 | pubmed:abstractText | Macrophage inflammatory protein-1 (MIP) is a recently cloned cytokine that causes neutrophilic infiltration and induces an inflammatory response. We studied the effect of MIP-1 alpha on histamine secretion from basophils and mast cells. Leukocytes from allergic and normal subjects were studied. MIP-1 alpha caused dose-dependent release of histamine from basophils of 14 of 20 allergic donors at concentrations of 10(-9)-10(-7) M, and the mean release was 13.50 +/- 2.9% at the highest concentration. In the same experiments, the mean histamine release by anti-immunoglobulin E and monocyte chemotactic and activating factor (MCAF) (10(-7) M) was 32 +/- 7% and 31 +/- 3%, respectively. The cells from only 2 of 10 normal subjects released histamine in response to MIP-1 alpha. Histamine release by MIP-1 alpha was rapid, and almost complete within the first 3 min. MIP-1 alpha-induced degranulation was a calcium-dependent noncytotoxic process. MIP-1 alpha showed chemotactic activity for purified basophils that was comparable to MCAF. Both MIP-1 alpha and MCAF at 10(-7) M concentration elicited a chemotactic response that was 40% of the maximal response to C5a (1 microgram/ml). Murine MIP-1 alpha induced histamine release from mouse peritoneal mast cells in a dose-dependent manner. Thus, we have established that MIP-1 alpha is a novel activator of basophils and mast cells. | lld:pubmed |
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| pubmed-article:1512541 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1512541 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1512541 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1512541 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1512541 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1512541 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:1512541 | pubmed:author | pubmed-author:GrantJ AJA | lld:pubmed |
| pubmed-article:1512541 | pubmed:author | pubmed-author:StaffordSS | lld:pubmed |
| pubmed-article:1512541 | pubmed:author | pubmed-author:Lett-BrownM... | lld:pubmed |
| pubmed-article:1512541 | pubmed:author | pubmed-author:AlamRR | lld:pubmed |
| pubmed-article:1512541 | pubmed:author | pubmed-author:ForsytheP APA | lld:pubmed |
| pubmed-article:1512541 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1512541 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1512541 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:1512541 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1512541 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1512541 | pubmed:pagination | 781-6 | lld:pubmed |
| pubmed-article:1512541 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1512541 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1512541 | pubmed:articleTitle | Macrophage inflammatory protein-1 alpha activates basophils and mast cells. | lld:pubmed |
| pubmed-article:1512541 | pubmed:affiliation | Department of Internal Medicine, University of Texas Medical Branch, Galveston 77550. | lld:pubmed |
| pubmed-article:1512541 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1512541 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1512541 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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