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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-9-30
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pubmed:abstractText |
Macrophage inflammatory protein-1 (MIP) is a recently cloned cytokine that causes neutrophilic infiltration and induces an inflammatory response. We studied the effect of MIP-1 alpha on histamine secretion from basophils and mast cells. Leukocytes from allergic and normal subjects were studied. MIP-1 alpha caused dose-dependent release of histamine from basophils of 14 of 20 allergic donors at concentrations of 10(-9)-10(-7) M, and the mean release was 13.50 +/- 2.9% at the highest concentration. In the same experiments, the mean histamine release by anti-immunoglobulin E and monocyte chemotactic and activating factor (MCAF) (10(-7) M) was 32 +/- 7% and 31 +/- 3%, respectively. The cells from only 2 of 10 normal subjects released histamine in response to MIP-1 alpha. Histamine release by MIP-1 alpha was rapid, and almost complete within the first 3 min. MIP-1 alpha-induced degranulation was a calcium-dependent noncytotoxic process. MIP-1 alpha showed chemotactic activity for purified basophils that was comparable to MCAF. Both MIP-1 alpha and MCAF at 10(-7) M concentration elicited a chemotactic response that was 40% of the maximal response to C5a (1 microgram/ml). Murine MIP-1 alpha induced histamine release from mouse peritoneal mast cells in a dose-dependent manner. Thus, we have established that MIP-1 alpha is a novel activator of basophils and mast cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-1371775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-1569397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-1689975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-1692035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-1693929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-1697311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-1709678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-1997656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-2419443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-2439589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-2469713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-2469718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-2473400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-2582257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-2687068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-3279154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-3290382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-3549897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-3805541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-6323602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-65434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1512541-66288
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
781-6
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1512541-Animals,
pubmed-meshheading:1512541-Basophils,
pubmed-meshheading:1512541-Calcium,
pubmed-meshheading:1512541-Chemokine CCL4,
pubmed-meshheading:1512541-Chemotaxis,
pubmed-meshheading:1512541-Cytokines,
pubmed-meshheading:1512541-Histamine,
pubmed-meshheading:1512541-Humans,
pubmed-meshheading:1512541-Kinetics,
pubmed-meshheading:1512541-Macrophage Inflammatory Proteins,
pubmed-meshheading:1512541-Mast Cells,
pubmed-meshheading:1512541-Mice,
pubmed-meshheading:1512541-Mice, Inbred DBA,
pubmed-meshheading:1512541-Monokines
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pubmed:year |
1992
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pubmed:articleTitle |
Macrophage inflammatory protein-1 alpha activates basophils and mast cells.
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pubmed:affiliation |
Department of Internal Medicine, University of Texas Medical Branch, Galveston 77550.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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