Linked Life Data

151240

Source:http://linkedlifedata.com/resource/pubmed/id/151240

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1978-12-2
pubmed:abstractText
Hemicastration of male rats produced rapid changes in plasma testosterone (T) levels both in summer and in winter. However, in winter, after unilateral castration, the duration of T maximum decrease was found to be longer, but the compensatory increase of blood T following its drop was more dramatic as compared to the summer season. The intraperitoneal (i.p.) 5-hydroxytryptophan (5-HTP) administration blocked the compensatory increase in plasma T that followed its drop induced by hemicastration. At the same time, under similar experimental conditions, a preliminary injection of p-chlorophenyl-alanine (PCPA) was accompanied by a more marked rise of plasma T than in control unilaterally castrated rats. After the injection of serotonin (5-HT) into the lateral ventricle of the brain there was no effect on the blood T content in rats with intact gonads. However, 5-HT injection to hemicastrated animals under similar conditions completely prevented the compensatory increase of T level in blood after its fall caused by the operation. On the other hand, double intraventricular injection of methysergide was followed by a more marked rise of blood T content as compared with the control hemicastrated rats. The conclusion is drawn that brain serotoninergic neurons are involved in feedback mechanisms related to the control of hypothalamic-pituitary-testicular complex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
359-66
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Role of serotonin in feedback control of hypothalamic-pituitary-testicular complex in male rats.
pubmed:publicationType
Journal Article