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pubmed-article:15124095pubmed:abstractTextThe EtOH extract of gardenia (Gardenia jasminoides Ellis) fruits was previously found to possess potent anti-angiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay. Bioassay-guided fractionation and purification of the EtOH extract yielded an active anti-angiogenic compound, which was determined to be an iridoid glucoside, geniposide, by spectral analyses. Geniposide showed anti-angiogenic activity in a dose-dependent manner. It also exhibited an inhibitory effect in the range of 25-100 microM on the growth of the transformed NIH3T3 cell line.lld:pubmed
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pubmed-article:15124095pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15124095pubmed:articleTitleGeniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides.lld:pubmed
pubmed-article:15124095pubmed:affiliationCollege of Pharmacy, Sookmyung Women's University, Seoul, Korea.lld:pubmed
pubmed-article:15124095pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15124095pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed