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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-5-4
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pubmed:abstractText |
The EtOH extract of gardenia (Gardenia jasminoides Ellis) fruits was previously found to possess potent anti-angiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay. Bioassay-guided fractionation and purification of the EtOH extract yielded an active anti-angiogenic compound, which was determined to be an iridoid glucoside, geniposide, by spectral analyses. Geniposide showed anti-angiogenic activity in a dose-dependent manner. It also exhibited an inhibitory effect in the range of 25-100 microM on the growth of the transformed NIH3T3 cell line.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0032-0943
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
467-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15124095-Angiogenesis Inhibitors,
pubmed-meshheading:15124095-Animals,
pubmed-meshheading:15124095-Chickens,
pubmed-meshheading:15124095-Choroidal Neovascularization,
pubmed-meshheading:15124095-Dose-Response Relationship, Drug,
pubmed-meshheading:15124095-Fruit,
pubmed-meshheading:15124095-Gardenia,
pubmed-meshheading:15124095-Iridoids,
pubmed-meshheading:15124095-Phytotherapy,
pubmed-meshheading:15124095-Plant Extracts,
pubmed-meshheading:15124095-Pyrans
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pubmed:year |
2004
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pubmed:articleTitle |
Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides.
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pubmed:affiliation |
College of Pharmacy, Sookmyung Women's University, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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