Linked Life Data

15123345

Source:http://linkedlifedata.com/resource/pubmed/id/15123345

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-5-4
pubmed:abstractText
The aim of this study was to determine whether spatial learning deficits in aged rats are associated with a loss of hippocampal synapses. The Morris water maze task was used to assess the spatial learning capacity of young and aged rats and to attribute aged animals to learning-impaired and learning-unimpaired groups. The number of axospinous synapses in the entire volume of the CA1 stratum radiatum was estimated with unbiased stereological techniques. The results show that the total number of all axospinous synapses and of their perforated and nonperforated subtypes remains constant in the CA1 stratum radiatum of aged learning-impaired rats as compared to aged learning-unimpaired rats and to young adults. Thus, neither age-related deficits in spatial learning nor advanced chronological age are associated with a loss of axospinous synapses from the rat CA1 stratum radiatum.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0197-4580
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
407-16
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum.
pubmed:affiliation
Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA. yurig@northwestern.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.