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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9419
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pubmed:dateCreated |
2004-5-3
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pubmed:abstractText |
Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1474-547X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
363
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1439-41
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pubmed:dateRevised |
2008-9-9
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pubmed:meshHeading |
pubmed-meshheading:15121408-Acute Disease,
pubmed-meshheading:15121408-Adult,
pubmed-meshheading:15121408-Child,
pubmed-meshheading:15121408-Chromosomes, Human, X,
pubmed-meshheading:15121408-Chromosomes, Human, Y,
pubmed-meshheading:15121408-Female,
pubmed-meshheading:15121408-Graft vs Host Disease,
pubmed-meshheading:15121408-Haploidy,
pubmed-meshheading:15121408-Humans,
pubmed-meshheading:15121408-Immunosuppression,
pubmed-meshheading:15121408-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15121408-Intestinal Mucosa,
pubmed-meshheading:15121408-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:15121408-Male,
pubmed-meshheading:15121408-Mesenchymal Stem Cell Transplantation,
pubmed-meshheading:15121408-Mesenchymal Stem Cells,
pubmed-meshheading:15121408-Transplantation, Homologous,
pubmed-meshheading:15121408-Transplantation Chimera
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pubmed:year |
2004
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pubmed:articleTitle |
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells.
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pubmed:affiliation |
Division of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden. Katarina.Leblanc@medhs.ki.se
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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