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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2004-5-3
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pubmed:abstractText |
Our research program uses genetic linkage and association analysis to identify human seizure sensitivity and resistance alleles. Quantitative trait loci mapping in mice led to identification of genetic variation in the potassium ion channel gene Kcnj10, implicating it as a putative seizure susceptibility gene. The purpose of this work was to translate these animal model data to a human genetic association study.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0920-1211
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pubmed:author |
pubmed-author:BerrettiniW HWH,
pubmed-author:BuonoR JRJ,
pubmed-author:DlugosD JDJ,
pubmed-author:FerraroT NTN,
pubmed-author:GoldenG TGT,
pubmed-author:LohoffF WFW,
pubmed-author:O'ConnorM JMJ,
pubmed-author:RyanS GSG,
pubmed-author:SanderTT,
pubmed-author:ScattergoodT MTM,
pubmed-author:SperlingM RMR,
pubmed-author:ZhaoHH
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-83
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15120748-Chi-Square Distribution,
pubmed-meshheading:15120748-Confidence Intervals,
pubmed-meshheading:15120748-Gene Frequency,
pubmed-meshheading:15120748-Genetic Predisposition to Disease,
pubmed-meshheading:15120748-Genetic Variation,
pubmed-meshheading:15120748-Genotype,
pubmed-meshheading:15120748-Humans,
pubmed-meshheading:15120748-Odds Ratio,
pubmed-meshheading:15120748-Potassium Channels,
pubmed-meshheading:15120748-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:15120748-Quantitative Trait Loci,
pubmed-meshheading:15120748-Seizures
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pubmed:year |
2004
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pubmed:articleTitle |
Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility.
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pubmed:affiliation |
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, 415 Curie Boulevard, CRB-120, Philadelphia, PA 19104-6140, USA. rjbuono@mail.med.upenn.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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