Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2004-5-3
pubmed:abstractText
In mice, withdrawal from agents that depress central nervous system function, such as barbiturates and benzodiazepines, results in the production of a withdrawal syndrome, one feature of which is increased severity of handling induced convulsions (HICs). High and Low Pentobarbital Withdrawal mice (HPW and LPW) were selectively bred to display severe and mild pentobarbital withdrawal HICs, respectively. These mice provide a valuable means to assess genetic correlations between withdrawal from pentobarbital and other sedative agents. We tested HPW and LPW mice for severity of HICs elicited during withdrawal from ethanol, diazepam, and zolpidem, and measured consumption of and preference for pentobarbital solutions in HPW and LPW mice. HPW mice displayed greater HICs than LPW mice during ethanol and zolpidem withdrawal, but differed less robustly during diazepam withdrawal. LPW mice consumed more pentobarbital in a solution of a moderate concentration than did HPW mice, but did not consume more pentobarbital at a higher or lower concentration. These results indicate that some of the same genes that affect the severity of withdrawal from pentobarbital also influence ethanol and zolpidem withdrawal, but that diazepam withdrawal may be less influenced by these genes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
1009
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-25
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15120579-Analysis of Variance, pubmed-meshheading:15120579-Animals, pubmed-meshheading:15120579-Anticonvulsants, pubmed-meshheading:15120579-Behavior, Animal, pubmed-meshheading:15120579-Central Nervous System Depressants, pubmed-meshheading:15120579-Diazepam, pubmed-meshheading:15120579-Drinking Behavior, pubmed-meshheading:15120579-Ethanol, pubmed-meshheading:15120579-Female, pubmed-meshheading:15120579-Hypnotics and Sedatives, pubmed-meshheading:15120579-Male, pubmed-meshheading:15120579-Mice, pubmed-meshheading:15120579-Mice, Inbred C57BL, pubmed-meshheading:15120579-Mice, Inbred DBA, pubmed-meshheading:15120579-Pentobarbital, pubmed-meshheading:15120579-Pyridines, pubmed-meshheading:15120579-Seizures, pubmed-meshheading:15120579-Selection, Genetic, pubmed-meshheading:15120579-Species Specificity, pubmed-meshheading:15120579-Substance Withdrawal Syndrome, pubmed-meshheading:15120579-Time Factors
pubmed:year
2004
pubmed:articleTitle
Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugs.
pubmed:affiliation
Department of Behavioral Neuroscience, Oregon Health & Science University and the Portland Alcohol Research Center, Veterans Affairs Medical Center, c/o Portland VA Medical Center, Portland, OR 97239, USA. kliether@ohsu.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.