Source:http://linkedlifedata.com/resource/pubmed/id/15120446
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
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| pubmed:dateCreated |
2004-5-3
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| pubmed:abstractText |
The effect of 50% ethanolic extract of Utleria salicifolia (USE) was assessed in different acute and chronic gastric ulcer models in rats. USE, 50-200 mg/kg administered orally, twice daily for 5 days showed dose-dependent ulcer protective effect in pylorus ligation (14.48-51.03% protection, P < 0.5 to P < 0.01), aspirin (28.80-56.52% protection, P < 0.5 to P < 0.001), ethanol (13.22-60.74% protection, P < 0.5 to P < 0.001), cold-restraint stress (21.22-77.14% protection, P < 0.05 to P < 0.001), and acetic acid (20.0-84.37% protection, P < 0.5 to P < 0.001)-induced acute and chronic ulcers. USE also significantly (P < 0.001) reduced the ulcer incidence (50 and 10%) and severity (67.83 and 91.34% protection) of duodenal ulcer, induced by cysteamine. Besides USE offered protection (53.52 and 60.58%) against ethanol-induced depletion of gastric wall mucus. However, USE reduced the ulcer index with significant decrease in plasma corticosterone (25.53 and 39.52% protection, P < 0.1 and P < 0.05), lipid peroxidation (18.75 and 47.92% protection, P < 0.01 and P < 0.001), superoxide dismutase (15.80 and 26.61% protection, P < 0.05 and P < 0.001) and increased in catalase (28.42 and 71.0% protection, P < 0.05 and P < 0.001) activity, respectively. Preliminary phytochemical screening of the USE gave the positive test for steroids, alkaloids, terpenoids, saponins and tannins. The HPTLC studies in the toluene: ethyl acetate: formic acid and the densitometric scanning at 254 nm gave three major spots with area corresponding to 28.16, 17.17, and 13.79% at 0.69, 0.78, and 0.88 R(f) values, respectively. The results indicate that USE possesses antiulcer activity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Ulcer Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Aspirin,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanol,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0378-8741
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
91
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
243-9
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| pubmed:meshHeading |
pubmed-meshheading:15120446-Acetic Acid,
pubmed-meshheading:15120446-Administration, Oral,
pubmed-meshheading:15120446-Animals,
pubmed-meshheading:15120446-Anti-Ulcer Agents,
pubmed-meshheading:15120446-Antioxidants,
pubmed-meshheading:15120446-Aspirin,
pubmed-meshheading:15120446-Dose-Response Relationship, Drug,
pubmed-meshheading:15120446-Duodenal Ulcer,
pubmed-meshheading:15120446-Ethanol,
pubmed-meshheading:15120446-Gastric Mucosa,
pubmed-meshheading:15120446-Lipid Peroxidation,
pubmed-meshheading:15120446-Phytotherapy,
pubmed-meshheading:15120446-Plant Extracts,
pubmed-meshheading:15120446-Plants, Medicinal,
pubmed-meshheading:15120446-Rats,
pubmed-meshheading:15120446-Rats, Sprague-Dawley,
pubmed-meshheading:15120446-Rhizome,
pubmed-meshheading:15120446-Stomach Ulcer
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| pubmed:year |
2004
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| pubmed:articleTitle |
Antiulcer activity of Utleria salicifolia rhizome extract.
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| pubmed:affiliation |
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Council of Scientific and Industrial Research, Rana Pratap Marg, P.O. Box 436, Lucknow 226 001, Uttar Pradesh, India. chvrao72@yahoo.com
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| pubmed:publicationType |
Journal Article
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