Linked Life Data

15119933

Source:http://linkedlifedata.com/resource/pubmed/id/15119933

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-5-3
pubmed:abstractText
This review summarizes our findings concerning the altered balance of vasoactive systems (namely sympathetic nervous system and nitric oxide) in various forms of experimental hypertension--genetic hypertension (SHR, HTG rats), salt hypertension (Dahl rats) and NO-deficient hypertension (L-NAME-treated rats). An attempt is made to define relative NO deficiency (compared to the existing level of sympathetic vasoconstriction), to describe its possible causes and to evaluate particular indicators of its extent. A special attention is paid to reactive oxygen species, their interaction with NO metabolism, cell Ca2+ handling and blood pressure regulation. Our current effort is focused on the investigation of abnormal regulation of cytosolic Ca2+ levels in smooth muscle and endothelium of hypertensive animals. Such a research should clarify the mechanisms by which genetic and/or environmental factors could chronically modify blood pressure level.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0862-8408
pubmed:author
pubmed:issnType
Print
pubmed:volume
53 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S23-34
pubmed:dateRevised
2008-4-2
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Altered balance of vasoactive systems in experimental hypertension: the role of relative NO deficiency.
pubmed:affiliation
CECR and Department of Experimental Hypertension, Institute of Physiology, Prague, Czech Republic.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't