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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5678
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pubmed:dateCreated |
2004-6-18
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pubmed:abstractText |
Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution in the adult brain that suggests specialization for synapses with different properties of release. Consistent with this distribution, inactivation of the VGLUT1 gene silenced a subset of excitatory neurons in the adult. However, the same cell populations exhibited VGLUT1-independent transmission early in life. Developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity. The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Slc17a6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Slc17a7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Glutamate Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Glutamate Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Transport Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
304
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1815-9
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:15118123-Animals,
pubmed-meshheading:15118123-Animals, Newborn,
pubmed-meshheading:15118123-Brain,
pubmed-meshheading:15118123-Carrier Proteins,
pubmed-meshheading:15118123-Cell Membrane,
pubmed-meshheading:15118123-Cells, Cultured,
pubmed-meshheading:15118123-Cerebellum,
pubmed-meshheading:15118123-Excitatory Postsynaptic Potentials,
pubmed-meshheading:15118123-Glutamic Acid,
pubmed-meshheading:15118123-Hippocampus,
pubmed-meshheading:15118123-In Situ Hybridization,
pubmed-meshheading:15118123-Membrane Transport Proteins,
pubmed-meshheading:15118123-Mice,
pubmed-meshheading:15118123-Mice, Knockout,
pubmed-meshheading:15118123-Nerve Tissue Proteins,
pubmed-meshheading:15118123-Neurons,
pubmed-meshheading:15118123-Patch-Clamp Techniques,
pubmed-meshheading:15118123-Purkinje Cells,
pubmed-meshheading:15118123-Pyramidal Cells,
pubmed-meshheading:15118123-Synapses,
pubmed-meshheading:15118123-Synaptic Transmission,
pubmed-meshheading:15118123-Synaptic Vesicles,
pubmed-meshheading:15118123-Vesicular Glutamate Transport Protein 1,
pubmed-meshheading:15118123-Vesicular Glutamate Transport Protein 2,
pubmed-meshheading:15118123-Vesicular Transport Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites.
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pubmed:affiliation |
Department of Neurology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine, CA 94143, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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