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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-4-29
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pubmed:abstractText |
The Boston Early-Onset COPD study showed that current or ex-smoking first degree relatives of severe early onset COPD probands have significantly lower forced expiratory volume in 1 second (FEV(1)) and FEV(1)/forced vital capacity (FVC) values than current or ex-smoking control subjects, which suggests the existence of genetic risk factors for the development of COPD in response to cigarette smoking. We hypothesised that first degree relatives of early onset COPD probands may also have lower values of spirometric parameters such as forced expiratory flow at the mid-portion of forced vital capacity (FEF(25-75)) and FEF(25-75)/FVC.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-10228129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-1081163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-11112130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-11704589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-2041257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-2923128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-300564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-302643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-3092709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-3366727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-3873193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-5448092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-571257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-6475921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-651978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-6742609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-7186226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-7199882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-7316275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-7362140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-9545414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-9620904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-970729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-9872837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15115866-9915570
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0040-6376
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
396-400
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15115866-Adolescent,
pubmed-meshheading:15115866-Adult,
pubmed-meshheading:15115866-Aged,
pubmed-meshheading:15115866-Aged, 80 and over,
pubmed-meshheading:15115866-Child,
pubmed-meshheading:15115866-Female,
pubmed-meshheading:15115866-Forced Expiratory Volume,
pubmed-meshheading:15115866-Humans,
pubmed-meshheading:15115866-Male,
pubmed-meshheading:15115866-Maximal Midexpiratory Flow Rate,
pubmed-meshheading:15115866-Middle Aged,
pubmed-meshheading:15115866-Pedigree,
pubmed-meshheading:15115866-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:15115866-Regression Analysis
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pubmed:year |
2004
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pubmed:articleTitle |
Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD.
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pubmed:affiliation |
Channing Laboratory and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. redld@channing.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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