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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-4-29
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pubmed:abstractText |
Screening of a computationally designed synthetic library led to the discovery of the N-phenylphenylglycines (NPPGs) as a novel class of human corticotropin releasing factor (h-CRF(1)) antagonists. Several NPPGs with greater potency than the original hit 1 were rapidly identified, and resolution of the racemate demonstrated that only the R-enantiomer displays activity. This structural class represents the first example of a non-peptide CRF(1) antagonist with a stereochemically distinct receptor binding affinity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:CraneChristine MCM,
pubmed-author:GrootenhuisPeter D JPD,
pubmed-author:GrossmanScottS,
pubmed-author:HassmanFredF,
pubmed-author:LordO COC,
pubmed-author:MillerKeith JKJ,
pubmed-author:MolteniValentinaV,
pubmed-author:PenzottiJulieJ,
pubmed-author:TerminAndreas PAP,
pubmed-author:WangTaoT,
pubmed-author:WilsonDean MDM,
pubmed-author:WongHarveyH
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2426-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:15115386-Animals,
pubmed-meshheading:15115386-Combinatorial Chemistry Techniques,
pubmed-meshheading:15115386-Dogs,
pubmed-meshheading:15115386-Drug Design,
pubmed-meshheading:15115386-Glycine,
pubmed-meshheading:15115386-Humans,
pubmed-meshheading:15115386-Models, Molecular,
pubmed-meshheading:15115386-Molecular Conformation,
pubmed-meshheading:15115386-Receptors, Corticotropin-Releasing Hormone,
pubmed-meshheading:15115386-Stereoisomerism,
pubmed-meshheading:15115386-Structure-Activity Relationship
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pubmed:year |
2004
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pubmed:articleTitle |
N-phenylphenylglycines as novel corticotropin releasing factor receptor antagonists.
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pubmed:affiliation |
Bristol-Myers Squibb Pharma Research Laboratories, 4570 Executive Drive, Suite 400, San Diego, California 92121, USA.
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pubmed:publicationType |
Journal Article
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