Source:http://linkedlifedata.com/resource/pubmed/id/15114506
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2004-4-28
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pubmed:abstractText |
Twenty-three Amaryllidaceae alkaloids having several different ring types were evaluated for their acetylcholinesterase enzyme (AChE) inhibitory activity. The alkaloid 1- O-acetyllycorine (IC50 : 0.96 +/- 0.04) showed significant AChE inhibitory activity. In addition, crinine (IC50 : 461 +/- 14), crinamidine (IC50 : 300 +/- 27), epivittatine (IC50 : 239 +/- 9), 6-hydroxycrinamine (IC50 : 490 +/- 7), N-desmethyl-8alpha-ethoxypretazettine (IC50 : 234 +/- 13) N-desmethyl-8beta-ethoxypretazettine (IC50 : 419 +/- 8), lycorine (IC50 : 213 +/- 1), and 1,2-di- O-acetyllycorine (IC50 : 211 +/- 10) had weak activity. Lycorine-type alkaloids were the most active alkaloids with 1- O-acetyllycorine exhibiting inhibitory effects two-fold more potent than that of galanthamine.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0032-0943
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
260-2
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15114506-Acetylcholinesterase,
pubmed-meshheading:15114506-Alkaloids,
pubmed-meshheading:15114506-Alzheimer Disease,
pubmed-meshheading:15114506-Angiosperms,
pubmed-meshheading:15114506-Cholinesterase Inhibitors,
pubmed-meshheading:15114506-Humans,
pubmed-meshheading:15114506-Inhibitory Concentration 50,
pubmed-meshheading:15114506-Phytotherapy,
pubmed-meshheading:15114506-Plant Extracts
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pubmed:year |
2004
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pubmed:articleTitle |
Acetylcholinesterase enzyme inhibitory effects of amaryllidaceae alkaloids.
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pubmed:affiliation |
Research Centre for Plant Growth and Development, School of Botany and Zoology, University of Natal Pietermaritzburg, South Africa.
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pubmed:publicationType |
Letter,
Research Support, Non-U.S. Gov't
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