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rdf:type |
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lifeskim:mentions |
umls-concept:C0003308,
umls-concept:C0015852,
umls-concept:C0025942,
umls-concept:C0053065,
umls-concept:C0087066,
umls-concept:C0204727,
umls-concept:C0205409,
umls-concept:C0205460,
umls-concept:C0320027,
umls-concept:C0441655,
umls-concept:C0871161
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pubmed:issue |
2
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pubmed:dateCreated |
2004-4-28
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pubmed:abstractText |
Three new beauvericins, designated beauvericins D, E and F, were isolated along with known beauvericin and beauvericin A, from the culture of Beauveria sp. FKI-1366 by solvent extraction, ODS column chromatography and HPLC. These compounds potentiate miconazole activity against not only wild Candida albicans but also fluconazole resistant C. albicans. Beauvericins D and E decreased the IC50 value of miconazole against fluconazole resistant C. albicans from 1.3 microM to 0.25 and 0.31 microM, respectively.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
110-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15112959-Antifungal Agents,
pubmed-meshheading:15112959-Ascomycota,
pubmed-meshheading:15112959-Candida albicans,
pubmed-meshheading:15112959-Chromatography, High Pressure Liquid,
pubmed-meshheading:15112959-Depsipeptides,
pubmed-meshheading:15112959-Drug Resistance, Fungal,
pubmed-meshheading:15112959-Drug Synergism,
pubmed-meshheading:15112959-Fermentation,
pubmed-meshheading:15112959-Fluconazole,
pubmed-meshheading:15112959-Macrolides,
pubmed-meshheading:15112959-Miconazole,
pubmed-meshheading:15112959-Microbial Sensitivity Tests,
pubmed-meshheading:15112959-Microscopy, Electron, Scanning
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pubmed:year |
2004
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pubmed:articleTitle |
New beauvericins, potentiators of antifungal miconazole activity, Produced by Beauveria sp. FKI-1366. I. Taxonomy, fermentation, isolation and biological properties.
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pubmed:affiliation |
Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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