Source:http://linkedlifedata.com/resource/pubmed/id/15112906
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2004-4-28
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| pubmed:abstractText |
Few studies have described the genetics of childhood diabetes mellitus (DM) in US minorities. High-risk DQA1 and DQB1 alleles (DQA1*0301, DQB1*0201, and DQB1*0302 in African Americans and Latinos, and DQA1 *0501 in African Americans) were identified from previous studies and tested in 45 African American and 26 Latino patients from the population-based Chicago Childhood Diabetes Registry, and in 50 healthy race-matched controls. Sixteen of the African American patients and three Latinos had youth-onset type 2 DM and were analyzed separately. In African Americans with type 1 DM, both DQA1*0102 and DQB1*0602 were protective (p < 0.0001), and the susceptibility alleles DQA1*0301 and DQB1*0201 were more frequent than in controls (p < 0.01). In Latinos, DQA1*0301 and DQB1*0302 were marginally increased in patients with DM1 compared to controls; no individual DQA1 or DQB1 allele was protective. Patients with DM1 were significantly more likely to carry one or two high-risk DQA1 alleles in both populations; they were also more likely than controls to carry at least one high-risk DQB1 allele. The odds ratio for the ability to form at least two high-risk DQA1-DQB1 heterodimers (cis and/or trans) was 7.9 (95% CI: 1.7-40.0) for African Americans and 5.7 (1.3-25.6) for Latinos with DM1. African American patients with DM2 were not statistically different from controls, and were less likely to carry four high-risk susceptibility alleles than patients with DM1 (p = 0.002). Many of the HLA-DQ associations previously documented in non-Hispanic White populations also are found in African Americans and Latinos with DM1, although some differences exist.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Genetic Markers,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ alpha-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ beta-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQA1 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQB1 antigen
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
0334-018X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
297-306
|
| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:15112906-Adolescent,
pubmed-meshheading:15112906-Adult,
pubmed-meshheading:15112906-African Americans,
pubmed-meshheading:15112906-Alleles,
pubmed-meshheading:15112906-Chicago,
pubmed-meshheading:15112906-Child,
pubmed-meshheading:15112906-Child, Preschool,
pubmed-meshheading:15112906-Diabetes Mellitus,
pubmed-meshheading:15112906-Female,
pubmed-meshheading:15112906-Genetic Markers,
pubmed-meshheading:15112906-Genetic Predisposition to Disease,
pubmed-meshheading:15112906-Genetic Testing,
pubmed-meshheading:15112906-HLA-DQ Antigens,
pubmed-meshheading:15112906-HLA-DQ alpha-Chains,
pubmed-meshheading:15112906-HLA-DQ beta-Chains,
pubmed-meshheading:15112906-Hispanic Americans,
pubmed-meshheading:15112906-Humans,
pubmed-meshheading:15112906-Male,
pubmed-meshheading:15112906-Pilot Projects,
pubmed-meshheading:15112906-Pregnancy,
pubmed-meshheading:15112906-Registries
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| pubmed:year |
2004
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| pubmed:articleTitle |
HLA-DQA1 and -DQB1 alleles in Latino and African American children with diabetes mellitus.
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| pubmed:affiliation |
Division of Epidemiology and Biostatistics, University of Illinois at Chicago, School of Public Health, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|