Source:http://linkedlifedata.com/resource/pubmed/id/15111933
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0013018,
umls-concept:C0085358,
umls-concept:C0333678,
umls-concept:C0439228,
umls-concept:C0472699,
umls-concept:C0750480,
umls-concept:C0856825,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1552961,
umls-concept:C1706438,
umls-concept:C2603343,
umls-concept:C2698600,
umls-concept:C2698872
|
| pubmed:issue |
5
|
| pubmed:dateCreated |
2004-4-27
|
| pubmed:abstractText |
Chimerism analysis of hematopoietic cells has emerged as an essential tool in nonmyeloablative hematopoietic stem cell transplantation. We have investigated the development of donor chimerism in granulocytes and CD4(+) and CD8(+) T cells in blood and bone marrow of 24 patients with hematologic malignancies who received HLA-identical sibling peripheral blood stem cell grafts after conditioning with fludarabine and 2 Gy of total body irradiation. The T-cell chimerism of blood and bone marrow was tightly correlated. Complete donor chimerism was reached earlier in the granulocytes than in the T cells. Mixed T-cell chimerism was common at the time of onset of acute graft-versus-host disease (aGVHD), and both CD4(+) and CD8(+) donor T-cell chimerism increased with the occurrence of aGVHD grades II to IV (P =.0002 and P =.019, respectively). The rate of disappearance of recipient CD8(+) T cells was faster in patients with aGVHD grades II to IV than in patients without clinically significant aGVHD (P =.016). This observation indicates a role of graft-versus-lymphohematopoietic tissue reactions in creating complete donor T-cell chimerism. A donor CD8(+) T-cell count above the median on day +14 increased the risk of subsequent development of aGVHD grades II to IV (P =.003).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1083-8791
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
337-46
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15111933-Acute Disease,
pubmed-meshheading:15111933-Adult,
pubmed-meshheading:15111933-Aged,
pubmed-meshheading:15111933-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15111933-Female,
pubmed-meshheading:15111933-Graft vs Host Disease,
pubmed-meshheading:15111933-Graft vs Host Reaction,
pubmed-meshheading:15111933-Hematologic Neoplasms,
pubmed-meshheading:15111933-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:15111933-Histocompatibility Testing,
pubmed-meshheading:15111933-Humans,
pubmed-meshheading:15111933-Immunosuppressive Agents,
pubmed-meshheading:15111933-Leukocyte Count,
pubmed-meshheading:15111933-Lymphocyte Transfusion,
pubmed-meshheading:15111933-Male,
pubmed-meshheading:15111933-Middle Aged,
pubmed-meshheading:15111933-Prognosis,
pubmed-meshheading:15111933-Time Factors,
pubmed-meshheading:15111933-Tissue Donors,
pubmed-meshheading:15111933-Transplantation, Homologous,
pubmed-meshheading:15111933-Transplantation, Isogeneic,
pubmed-meshheading:15111933-Transplantation Chimera
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Chimerism studies in HLA-identical nonmyeloablative hematopoietic stem cell transplantation point to the donor CD8(+) T-cell count on day + 14 as a predictor of acute graft-versus-host disease.
|
| pubmed:affiliation |
Department of Hematology, Rigshospitalet, Copenhagen, Denmark. slykkep@rh.dk
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|