Linked Life Data

15111929

Source:http://linkedlifedata.com/resource/pubmed/id/15111929

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2004-4-27
pubmed:abstractText
CD134 (OX40) is expressed on activated CD4(+) donor T cells in allogeneic stem cell transplant recipients with acute graft-versus-host disease. The data presented here reveal that differential expression of CD25 by CD4(+) CD134(+) T cells allows separation of these activated cells into 2 phenotypically and functionally distinct alloreactive T-cell subsets. These subsets exhibit distinct tissue associations, with CD4(+) CD134(+) CD25(-) T cells preferentially found in lymphoid tissues and CD4(+) CD134(+) CD25(+) T cells located in lymphoid tissues and inflamed extralymphoid tissues. The CD25(-) T-cell subset exhibited potent proliferative responses to both concanavalin A and allogeneic host leukocytes. By contrast, the CD25(+) T-cell subset proliferated minimally in response to either treatment and inhibited alloantigen-induced proliferation of the CD25(-) subset. Proliferative unresponsiveness associated with the CD25(+) T-cell subset did not extend to cytokine secretion. When stimulated with alloantigen, both CD4(+) CD134(+) T-cell subsets responded by secreting interferon-gamma and interleukin (IL)-10, and neither T-cell subset produced detectable levels of IL-2 or IL-4. Three-day treatment of the CD25(+) T-cell subset with IL-2 restored the proliferative responsiveness of these cells to host alloantigens, suggesting that the proliferative unresponsiveness associated with this T-cell subset reflected a requirement for IL-2. The preferential tissue associations and distinct functional properties associated with these separable alloreactive CD4(+) CD134(+) T-cell subsets suggest that they participate differentially in clinical graft-versus-host disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1083-8791
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
298-309
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15111929-Acute Disease, pubmed-meshheading:15111929-Animals, pubmed-meshheading:15111929-Bone Marrow Transplantation, pubmed-meshheading:15111929-CD4-Positive T-Lymphocytes, pubmed-meshheading:15111929-Cytokines, pubmed-meshheading:15111929-Graft vs Host Disease, pubmed-meshheading:15111929-Humans, pubmed-meshheading:15111929-Immunity, pubmed-meshheading:15111929-Lymphocyte Activation, pubmed-meshheading:15111929-Lymphocyte Transfusion, pubmed-meshheading:15111929-Rats, pubmed-meshheading:15111929-Rats, Inbred Strains, pubmed-meshheading:15111929-Receptors, Interleukin-2, pubmed-meshheading:15111929-Receptors, OX40, pubmed-meshheading:15111929-Receptors, Tumor Necrosis Factor, pubmed-meshheading:15111929-T-Lymphocyte Subsets, pubmed-meshheading:15111929-Tissue Distribution
pubmed:year
2004
pubmed:articleTitle
CD25 expression distinguishes functionally distinct alloreactive CD4 CD134 (OX40) T-cell subsets in acute graft-versus-host disease.
pubmed:affiliation
Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA. streetep@ohsu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.