Source:http://linkedlifedata.com/resource/pubmed/id/15110887
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2004-4-27
|
| pubmed:abstractText |
The aim was to determine the relevance of human papillomavirus (HPV) testing in identifying high-grade cervical intraepithelial neoplasia or worse (CIN2/3+) in a hospital population (n=3574) characterised by a high rate of cytological abnormalities and high-risk HPV infections. According to the results of the initial Papanicolaou and HPV test, women were directly referred for colposcopy/biopsy or recalled for a control visit. Sensitivity and specificity were corrected for verification bias. HPV-testing sensitivity was 94.3%, higher than that of cytological testing at any cut-off point (65.1%-86.8%), while specificity was greater for cytology than for HPV testing (99.3% or 91.8% versus 83.4%). The combination of both tests allowed 100% sensitivity and negative predictive value. We conclude that HPV testing is a relevant tool for the detection of cervical disease. The best way of combining cytology and HPV detection in screening programmes should be evaluated in large-scale studies.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0959-8049
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1225-32
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15110887-Adolescent,
pubmed-meshheading:15110887-Adult,
pubmed-meshheading:15110887-Aged,
pubmed-meshheading:15110887-Aged, 80 and over,
pubmed-meshheading:15110887-Cervical Intraepithelial Neoplasia,
pubmed-meshheading:15110887-Colposcopy,
pubmed-meshheading:15110887-DNA, Viral,
pubmed-meshheading:15110887-Female,
pubmed-meshheading:15110887-Follow-Up Studies,
pubmed-meshheading:15110887-Hospitalization,
pubmed-meshheading:15110887-Humans,
pubmed-meshheading:15110887-Mass Screening,
pubmed-meshheading:15110887-Middle Aged,
pubmed-meshheading:15110887-Papillomaviridae,
pubmed-meshheading:15110887-Papillomavirus Infections,
pubmed-meshheading:15110887-Precancerous Conditions,
pubmed-meshheading:15110887-Sensitivity and Specificity,
pubmed-meshheading:15110887-Tumor Virus Infections,
pubmed-meshheading:15110887-Uterine Cervical Neoplasms,
pubmed-meshheading:15110887-Vaginal Smears
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Detection of cervical precancer and cancer in a hospital population; benefits of testing for human papillomavirus.
|
| pubmed:affiliation |
Laboratoire de Biologie Cellulaire et Moléculaire, CHU de Besançon, Hôpital Jean Minjoz, 25030 Besançon cedex, France.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|