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pubmed-article:15110879pubmed:abstractTextA prospective randomised phase III study in patients < or =65 years old with previously untreated multiple myeloma (MM), intensive chemotherapy followed by myeloablative chemotherapy and autologous stem-cell rescue was compared with intensive chemotherapy alone. This economic evaluation was based on detailed data from patient charts and hospital information systems. In the intention-to-treat analysis, mean total treatment and follow-up costs of the myeloablative treatment arm were 81,643 euros compared to 68,802 euros for the chemotherapy arm (P=0.09). Costs per quality-adjusted life year were 51,357 euros versus 37,328 euros. In the clinical study, no significant differences were found in overall survival after a median follow-up of 33 months from randomisation. Intensive chemotherapy is regarded as standard therapy for younger patients with previously untreated MM. Cost-effectiveness of myeloma therapy after 3 years of follow up seems not to be favoured by myeloablative treatment with autologous stem-cell rescue.lld:pubmed
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pubmed-article:15110879pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15110879pubmed:articleTitleA cost-utility analysis comparing intensive chemotherapy alone to intensive chemotherapy followed by myeloablative chemotherapy with autologous stem-cell rescue in newly diagnosed patients with stage II/III multiple myeloma; a prospective randomised phase III study.lld:pubmed
pubmed-article:15110879pubmed:affiliationInstitute for Medical Technology Assessment, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands. vanagthoven@bmg.eur.nllld:pubmed
pubmed-article:15110879pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:15110879pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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pubmed-article:15110879pubmed:publicationTypeClinical Trial, Phase IIIlld:pubmed
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