Linked Life Data

15109719

Source:http://linkedlifedata.com/resource/pubmed/id/15109719

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-4-27
pubmed:abstractText
Helicobacter pylori is a human gastric pathogen which is extremely well adapted to its unique habitat. Crucial for the survival under the acidic conditions prevailing in the stomach is the enzyme urease. Transcriptome analysis has shown that transcription of a large number of genes responds to the exposure of H. pylori to acid including the genes encoding the urease subunits UreA and UreB as well as several genes which have been previously identified as target genes of the two-component system HP166-HP165. Here, we provide genetic evidence that a stimulus perceived by the histidine kinase HP165 is pH since increased transcription at acidic pH from the promoters controlling the expression of the ORFs hp119 and hp1432 which belong to the HP166-HP165 regulon is strictly dependent on the presence of histidine kinase HP165. Furthermore, we show that the basal transcription from the promoter of the ureA gene is modulated by the HP166-HP165 two-component system in response to acidic pH. On the other hand, the acid-induced increase in transcription of the promoter directing the expression of the orphan response regulator HP1021 is not controlled by the HP166-HP165 two-component system, nor is it mediated by HP1021 itself.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0378-1097
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
234
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-61
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15109719-Acids, pubmed-meshheading:15109719-Bacterial Proteins, pubmed-meshheading:15109719-Base Sequence, pubmed-meshheading:15109719-Conserved Sequence, pubmed-meshheading:15109719-Gene Expression Regulation, Bacterial, pubmed-meshheading:15109719-Genes, Bacterial, pubmed-meshheading:15109719-Helicobacter pylori, pubmed-meshheading:15109719-Hydrogen-Ion Concentration, pubmed-meshheading:15109719-Mutagenesis, Insertional, pubmed-meshheading:15109719-Promoter Regions, Genetic, pubmed-meshheading:15109719-Protein Kinases, pubmed-meshheading:15109719-RNA, Bacterial, pubmed-meshheading:15109719-RNA, Messenger, pubmed-meshheading:15109719-Regulon, pubmed-meshheading:15109719-Signal Transduction, pubmed-meshheading:15109719-Transcription, Genetic, pubmed-meshheading:15109719-Urease
pubmed:year
2004
pubmed:articleTitle
Genetic evidence for histidine kinase HP165 being an acid sensor of Helicobacter pylori.
pubmed:affiliation
Theodor-Boveri-Institut für Biowissenschaften, Lehrstuhl für Mikrobiologie, Universität Würzburg, Am Hubland, D-97074 Wuerzburg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't