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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-4-27
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pubmed:abstractText |
A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide, hydrazide, urea and 1-hydroxyprop-1-en-3-one moiety. Amide derivatives are the most promising ones and could serve as leads for further developments.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BénardChristopheC,
pubmed-author:BonnenfantSabineS,
pubmed-author:DanetMichèleM,
pubmed-author:DesmaëleDidierD,
pubmed-author:Le BretMarcM,
pubmed-author:LehHervéH,
pubmed-author:MbembaGladysG,
pubmed-author:MouscadetJean-FrançoisJF,
pubmed-author:Normand-BayleMarieM,
pubmed-author:ThomasClaire-MarieCM,
pubmed-author:ZouhiriFatimaF,
pubmed-author:d'AngeloJeanJ
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pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2473-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15109635-Cell Line,
pubmed-meshheading:15109635-Cell Survival,
pubmed-meshheading:15109635-Cross-Linking Reagents,
pubmed-meshheading:15109635-HIV Infections,
pubmed-meshheading:15109635-HIV Integrase,
pubmed-meshheading:15109635-HIV Integrase Inhibitors,
pubmed-meshheading:15109635-Humans,
pubmed-meshheading:15109635-Inhibitory Concentration 50,
pubmed-meshheading:15109635-Quinolines,
pubmed-meshheading:15109635-Structure-Activity Relationship,
pubmed-meshheading:15109635-Virion
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pubmed:year |
2004
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pubmed:articleTitle |
Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.
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pubmed:affiliation |
CNRS UMR 8076, Centre d'Etudes Pharmaceutiques, Chimie Organique, 5 rue J.-B. Clément, 92296 Châtenay-Malabry, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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