| pubmed-article:15108351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15108351 | lifeskim:mentions | umls-concept:C0029431 | lld:lifeskim |
| pubmed-article:15108351 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15108351 | lifeskim:mentions | umls-concept:C1417771 | lld:lifeskim |
| pubmed-article:15108351 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15108351 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15108351 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15108351 | pubmed:dateCreated | 2004-4-26 | lld:pubmed |
| pubmed-article:15108351 | pubmed:abstractText | A new superoxide-generating enzyme, NADPH oxidase 4 (Nox4), contributes to osteoclastic superoxide production. In this study, we demonstrated that Nox4 is expressed at a higher level in osteoclasts than that in precursor cells. This result suggested that Nox4 is upregulated during the differentiation and development of osteoclasts. Cotransfection of Nox4/P22 DNA resulted in enhanced superoxide production in osteoclasts, indicating that P22 may be a necessary factor for the Nox4 activity. In addition, expression of both cathepsin K and TRAP is increased significantly in osteoclasts cotransfected with Nox4/P22. Further study revealed that JNK was activated and that NF-kappa B was inhibited in Nox4/P22 cotransfected osteoclasts. These findings suggest that superoxide and/or superoxide derived molecules may modulate the signal transduction pathways necessary for osteoclasts to function. | lld:pubmed |
| pubmed-article:15108351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15108351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15108351 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15108351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15108351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15108351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15108351 | pubmed:month | May | lld:pubmed |
| pubmed-article:15108351 | pubmed:issn | 0730-2312 | lld:pubmed |
| pubmed-article:15108351 | pubmed:author | pubmed-author:YangSuS | lld:pubmed |
| pubmed-article:15108351 | pubmed:author | pubmed-author:RiesWilliamW | lld:pubmed |
| pubmed-article:15108351 | pubmed:author | pubmed-author:KeyLyndonL | lld:pubmed |
| pubmed-article:15108351 | pubmed:author | pubmed-author:ZhangYizhongY | lld:pubmed |
| pubmed-article:15108351 | pubmed:copyrightInfo | Copyright 2004 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:15108351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15108351 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15108351 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:15108351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15108351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15108351 | pubmed:pagination | 238-48 | lld:pubmed |
| pubmed-article:15108351 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15108351 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15108351 | pubmed:articleTitle | Expression of Nox4 in osteoclasts. | lld:pubmed |
| pubmed-article:15108351 | pubmed:affiliation | Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425,USA. yangs@musc.edu | lld:pubmed |
| pubmed-article:15108351 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15108351 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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