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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-4-26
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pubmed:abstractText |
A new superoxide-generating enzyme, NADPH oxidase 4 (Nox4), contributes to osteoclastic superoxide production. In this study, we demonstrated that Nox4 is expressed at a higher level in osteoclasts than that in precursor cells. This result suggested that Nox4 is upregulated during the differentiation and development of osteoclasts. Cotransfection of Nox4/P22 DNA resulted in enhanced superoxide production in osteoclasts, indicating that P22 may be a necessary factor for the Nox4 activity. In addition, expression of both cathepsin K and TRAP is increased significantly in osteoclasts cotransfected with Nox4/P22. Further study revealed that JNK was activated and that NF-kappa B was inhibited in Nox4/P22 cotransfected osteoclasts. These findings suggest that superoxide and/or superoxide derived molecules may modulate the signal transduction pathways necessary for osteoclasts to function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsin K,
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsins,
http://linkedlifedata.com/resource/pubmed/chemical/Ctsk protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nox4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0730-2312
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
238-48
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15108351-Animals,
pubmed-meshheading:15108351-Cathepsin K,
pubmed-meshheading:15108351-Cathepsins,
pubmed-meshheading:15108351-Cells, Cultured,
pubmed-meshheading:15108351-Gene Expression Regulation,
pubmed-meshheading:15108351-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:15108351-MAP Kinase Kinase 4,
pubmed-meshheading:15108351-Mice,
pubmed-meshheading:15108351-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:15108351-NADPH Oxidase,
pubmed-meshheading:15108351-NF-kappa B,
pubmed-meshheading:15108351-Osteoclasts,
pubmed-meshheading:15108351-Protein Binding,
pubmed-meshheading:15108351-RNA, Messenger,
pubmed-meshheading:15108351-Receptor, Macrophage Colony-Stimulating Factor,
pubmed-meshheading:15108351-Signal Transduction,
pubmed-meshheading:15108351-Superoxides,
pubmed-meshheading:15108351-Transfection
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pubmed:year |
2004
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pubmed:articleTitle |
Expression of Nox4 in osteoclasts.
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pubmed:affiliation |
Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425,USA. yangs@musc.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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