15107501

Source:http://linkedlifedata.com/resource/pubmed/id/15107501

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0085458, umls-concept:C0175967, umls-concept:C0242961, umls-concept:C0439581, umls-concept:C1547530, umls-concept:C1549081, umls-concept:C1692758, umls-concept:C1704686, umls-concept:C1705920
pubmed:issue	18
pubmed:dateCreated	2004-5-5
pubmed:abstractText	Chromosome replication origins were mapped in vivo in the two hyperthermophilic archaea, Sulfolobus acidocaldarius and Sulfolobus solfataricus, by using microarray-based marker frequency analysis. Bidirectional replication was found to be initiated in near synchrony from three separate sites in both organisms. Two of the three replication origins in each species were located in the vicinity of a cdc6/orc1 replication initiation gene, whereas no known replication-associated gene could be identified near the third origin in either organism. In contrast to initiation, replication termination occurred asynchronously, such that certain replication forks continued to progress for >40 min after the others had terminated. In each species, all replication forks advanced at similar DNA polymerization rates; this was found to be an order of magnitude below that displayed by Escherichia coli and thus closer to eukaryotic elongation rates. In S. acidocaldarius, a region containing short regularly spaced repeats was found to hybridize aberrantly, as compared to the rest of the chromosome, raising the possibility of a centromere-like function.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-10482507, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-10746779, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-10864870, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-10944214, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-11298289, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-11588253, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-12670964, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-14526006, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-14718164, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-2512283, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-270744, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-4559703, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-9215619, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-9260934, http://linkedlifedata.com/resource/pubmed/commentcorrection/15107501-9401018
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7505876
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0027-8424
pubmed:author	pubmed-author:AnderssonAndersA, pubmed-author:BernanderRolfR, pubmed-author:ChenLanmingL, pubmed-author:LundgrenMagnusM, pubmed-author:NilssonPeterP
pubmed:issnType	Print
pubmed:day	4
pubmed:volume	101
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	7046-51
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:15107501-Chromosomes, pubmed-meshheading:15107501-DNA Replication, pubmed-meshheading:15107501-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:15107501-Replication Origin, pubmed-meshheading:15107501-Sulfolobus
pubmed:year	2004
pubmed:articleTitle	Three replication origins in Sulfolobus species: synchronous initiation of chromosome replication and asynchronous termination.
pubmed:affiliation	Department of Molecular Evolution, Evolutionary Biology Center, Uppsala University, Norbyvägen 18C, SE-752 36 Uppsala, Sweden.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't