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pubmed-article:15107311pubmed:abstractTextDespite the efficacy of the BCR-ABL tyrosine kinase inhibitor Imatinib mesylate for the treatment of chronic myeloid leukemia (CML), resistance has been observed in a proportion of cases, especially those with advanced stages of the disease. Point mutations within the ABL kinase domain are emerging as the most frequent mechanism for reactivation of kinase activity within the leukemic clone.lld:pubmed
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pubmed-article:15107311pubmed:articleTitleDenaturing-HPLC-based assay for detection of ABL mutations in chronic myeloid leukemia patients resistant to Imatinib.lld:pubmed
pubmed-article:15107311pubmed:affiliationInstitute of Hematology and Medical Oncology Seràgnoli, University of Bologna, Bologna, Italy.lld:pubmed
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