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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-9-18
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pubmed:databankReference |
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pubmed:abstractText |
We isolated cDNA clones encoding a protein-tyrosine phosphatase (PTP) from a human T cell PEER cDNA library. The predicted open reading frame encodes a approximately 40-kDa protein composed of 360 amino acids and has no apparent hydrophobic segments, suggesting that it is a nontransmembrane PTP, which was designated as LC-PTP (leukocyte PTP). Northern blot analysis revealed that the LC-PTP mRNA was preferentially expressed in a variety of hematopoietic cells and the transcriptional sizes were approximately 4.0 kilobases and approximately 2.9 kilobases. Fluorescent in situ hybridization revealed that the human LC-PTP gene is located on the chromosome region 1q32.1, which is known to be a site associated with chromosomal deletion in malignant lymphomas, where candidate tumor suppressor genes might be present.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1607-15
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1510684-Amino Acid Sequence,
pubmed-meshheading:1510684-Base Sequence,
pubmed-meshheading:1510684-Blotting, Northern,
pubmed-meshheading:1510684-Chromosome Banding,
pubmed-meshheading:1510684-Chromosome Mapping,
pubmed-meshheading:1510684-Chromosomes, Human, Pair 1,
pubmed-meshheading:1510684-Cloning, Molecular,
pubmed-meshheading:1510684-DNA,
pubmed-meshheading:1510684-Genomic Library,
pubmed-meshheading:1510684-Humans,
pubmed-meshheading:1510684-Leukocytes,
pubmed-meshheading:1510684-Molecular Sequence Data,
pubmed-meshheading:1510684-Plasmids,
pubmed-meshheading:1510684-Protein Tyrosine Phosphatases,
pubmed-meshheading:1510684-RNA, Messenger,
pubmed-meshheading:1510684-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1510684-T-Lymphocytes,
pubmed-meshheading:1510684-Transcription, Genetic
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pubmed:year |
1992
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pubmed:articleTitle |
Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP.
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pubmed:affiliation |
Department of Internal Medicine (Section 1), Sapporo Medical College, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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