Linked Life Data

15106033

Source:http://linkedlifedata.com/resource/pubmed/id/15106033

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13-14
pubmed:dateCreated
2004-4-23
pubmed:abstractText
The amount of drug delivered from commercially available inhalation devices which reaches the lungs of preschool children is generally low. We therefore studied the efficiency of lung delivery from an optimised combination of delivery device and drug formulation based on individual patient-related factors. In six three-year-old children we compared the delivery of a radiolabelled budesonide solution with a MMD of 4.2 mm from a conventional nebuliser, with that of a radiolabelled budesonide solution with a MMD of 2.5 mm from a perforated vibrating membrane nebuliser. Lung deposition of budesonide delivered from the perforated vibrating membrane nebuliser was 36% and 38% and notably higher than from a conventional nebuliser (maximum 8%). The development of complementary combinations of delivery devices and drug formulations to meet the needs of efficient inhalation therapy in preschool children seems to be a good way of improving the efficacy of inhaled therapy in this age group.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1424-7860
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
198-200
pubmed:dateRevised
2011-2-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
A complementary combination of delivery device and drug formulation for inhalation therapy in preschool children.
pubmed:affiliation
Swiss Paediatric Respiratory Research Group, Division of Respirtatory Medicine, University Children's Hospital, Zurich, Switzerland.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't