Source:http://linkedlifedata.com/resource/pubmed/id/15105654
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2004-4-23
|
| pubmed:abstractText |
Atypical teratoid/rhabdoid tumor (AT/RT) may be misdiagnosed as primitive neuroectodermal tumor/medulloblastoma (PNET) and occasionally as other tumors. Molecular genetic analysis of AT/RT demonstrates deletion and mutation of the hSNF5/INI1 gene in most cases, with decreased or absent expression at the RNA or protein level. Immunohistochemistry with an antibody to INI1 was performed to determine whether this would be a sensitive and specific means of assessing INI1 loss in pediatric brain tumors. Fifty-three tumors consisting of 20 AT/RTs, 10 PNETs, and 23 other central nervous system tumors were examined. No nuclear staining was found in all 20 AT/RTs. Most other central nervous system tumors demonstrated nuclear staining. Eight cases in which classification as AT/RT or PNET was difficult were also examined. Seven cases had no chromosome 22 deletion or INI1 mutation; INI1 antibody showed nuclear staining in these cases. One case was a recurrent tumor with features consistent with an AT/RT. INI1 immunostaining was negative in this case, and a mutation in INI1 was subsequently identified. Immunohistochemical staining with an INI1 antibody correlates with molecular findings in AT/RT and may be useful in confirming the histologic diagnosis. INI1 immunostaining may have particular utility in the analysis of tumors with indeterminate histologic features or atypical immunophenotypic profiles.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0147-5185
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
644-50
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15105654-Adolescent,
pubmed-meshheading:15105654-Brain Neoplasms,
pubmed-meshheading:15105654-Cell Nucleus,
pubmed-meshheading:15105654-Child,
pubmed-meshheading:15105654-Child, Preschool,
pubmed-meshheading:15105654-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:15105654-Chromosome Deletion,
pubmed-meshheading:15105654-Chromosomes, Human, Pair 22,
pubmed-meshheading:15105654-DNA, Neoplasm,
pubmed-meshheading:15105654-DNA-Binding Proteins,
pubmed-meshheading:15105654-Female,
pubmed-meshheading:15105654-Humans,
pubmed-meshheading:15105654-Immunoenzyme Techniques,
pubmed-meshheading:15105654-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15105654-Infant,
pubmed-meshheading:15105654-Male,
pubmed-meshheading:15105654-Mutation,
pubmed-meshheading:15105654-Neuroectodermal Tumors, Primitive,
pubmed-meshheading:15105654-Rhabdoid Tumor,
pubmed-meshheading:15105654-Teratoma,
pubmed-meshheading:15105654-Transcription Factors,
pubmed-meshheading:15105654-Tumor Markers, Biological
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms.
|
| pubmed:affiliation |
Department of Pathology, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|