Source:http://linkedlifedata.com/resource/pubmed/id/15105645
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2004-4-23
|
| pubmed:abstractText |
Nodal tumor-forming accumulations of plasmacytoid monocytes/interferon-producing cells (PMs/IPCs) have been described in patients with myeloproliferative disorders. Here we report a series of 9 additional cases of such association. The patients were predominantly adult (median, 62 years), males (male/female ratio, 7:2), who presented with chronic myelomonocytic leukemia (4 cases), acute myeloid leukemia (1), acute monocytic leukemia (2), unclassifiable chronic myeloproliferative (1), or myeloproliferative/myelodysplastic disease (1). The prognosis was poor (median survival, 24 months) and related to progression of the underlying myeloid neoplasm. We found that in addition to lymph nodes, PMs/IPCs accumulated to bone marrow (8 cases) and skin (4 cases). Immunohistochemical markers typically expressed by PMs/IPCs (CD68, CLA/HECA452, CD123) were found in all cases and shown useful to identify cells with variations from classic morphology. In addition, PMs/IPCs expressed the interferon-alpha (IFN-alpha) inducible protein MxA, the B-cell oncogene TCL1, and granzyme B. The biologic and clinical significance of the association between PMs/IPCs and myeloid disorders remains not clarified. Using fluorescence in situ hybridization analysis in a case known to harbor monosomy 7 in the myeloid leukemia, we demonstrated that PMs/IPCs share the same chromosomal abnormality, thus indicating that they are clonal, neoplastic in nature, and closely related to the associated myeloid tumor. Recently, a novel CD56+ hematologic neoplasm has been reported and retained to stem from PMs/IPCs. The majority of PMs/IPCs in the present series failed to express CD56, thus indicating that variants of PMs/IPCs neoplasms exist, which might represent parts of a spectrum.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0147-5185
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| pubmed:author |
pubmed-author:FacchettiFabioF,
pubmed-author:FestaSilvanaS,
pubmed-author:FrizzeraGlaucoG,
pubmed-author:GrigolatoPiergiovanniP,
pubmed-author:MassarelliGiovanninoG,
pubmed-author:RemottiDanieleD,
pubmed-author:RosatiStefanoS,
pubmed-author:RossiElisaE,
pubmed-author:VergoniFedericaF,
pubmed-author:VermiWilliamW
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| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
585-95
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15105645-Adult,
pubmed-meshheading:15105645-Aged,
pubmed-meshheading:15105645-Aged, 80 and over,
pubmed-meshheading:15105645-Bone Marrow,
pubmed-meshheading:15105645-Clone Cells,
pubmed-meshheading:15105645-DNA, Neoplasm,
pubmed-meshheading:15105645-Female,
pubmed-meshheading:15105645-Humans,
pubmed-meshheading:15105645-Immunoenzyme Techniques,
pubmed-meshheading:15105645-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15105645-Interferons,
pubmed-meshheading:15105645-Interphase,
pubmed-meshheading:15105645-Leukemia,
pubmed-meshheading:15105645-Lymph Nodes,
pubmed-meshheading:15105645-Male,
pubmed-meshheading:15105645-Middle Aged,
pubmed-meshheading:15105645-Monocytes,
pubmed-meshheading:15105645-Myeloproliferative Disorders,
pubmed-meshheading:15105645-Plasma Cells,
pubmed-meshheading:15105645-Skin,
pubmed-meshheading:15105645-Tumor Markers, Biological
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Nodal and extranodal tumor-forming accumulation of plasmacytoid monocytes/interferon-producing cells associated with myeloid disorders.
|
| pubmed:affiliation |
Department of Pathology, University of Brescia, Brescia, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|