Linked Life Data

15104481

Source:http://linkedlifedata.com/resource/pubmed/id/15104481

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-4-23
pubmed:abstractText
Bioassay-directed fractionation of the CH(2)Cl(2)-MeOH extract of Clavularia viridis collected in Taiwan has afforded seven new prostanoids, designated as 4-deacetoxyl-12-O-deacetylclavulone I (1), 4-deacetoxyl-12-O-deacetylclavulone II (2), bromovulone II (4), iodovulone II (5), 4-deacetoxyl-12-O-deacetylclavulone III (6), bromovulone III (7), and iodovulone III (8), in addition to seven known prostanoids (clavulones I, II, III, 7-acetoxy-7,8-dihydroiodovulone, chlorovulones II, III, and 4-deacetoxylclavulone II (3, claviridenone E)). The structures of compounds 1-8 were determined on the basis of 1D and 2D NMR techniques including COSY, HSQC, and HMBC experiments. Pharmacological study revealed that bromovulone III (7) and chlorovulone II exhibited the most promising cytotoxicity against human prostate (PC-3) and colon (HT29) cancer cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0163-3864
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
542-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
New prostanoids with cytotoxic activity from Taiwanese octocoral Clavularia viridis.
pubmed:affiliation
Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't