Linked Life Data

15104180

Source:http://linkedlifedata.com/resource/pubmed/id/15104180

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-4-23
pubmed:abstractText
Calcium entry controls a plethora of short- and long-term cell functions. With respect to the activation mechanisms of Ca2+ entry channels they are subdivided in the thoroughly characterized voltage-gated Ca2+ channels and the non-voltage gated Ca2+ channels. The latter group includes cation channels of the 'transient receptor potential' (TRP) superfamily, which consists of three subfamilies (TRPC, TRPV, TRPM). Activation of TRP channels is not yet completely understood, but examples of activation mechanisms of TRP channels from all three subfamilies will be discussed. The main focus is on the members of the TRPV subfamily, among which the TRPV4 channel shows a surprising gating promiscuity. It can be activated by cell swelling, heat and phorbol esters. Endogenous activators of the channel have not yet been described. It will be shown that lipid messengers related to arachidonic acid are endogenous TRPV4 activators. For TRPV5 and 6, the only highly Ca2+ selective channels within the TRP super-family, a voltage-dependent gating mechanism will be discussed, which includes an open pore block by Mg2+ and a highly Ca2+-sensitive mechanism of inactivation. Regulation of channel availability by interaction with a protein bound to a site at the C-terminus of both channels will be demonstrated. Functional consequences of these different mechanisms of gating will be discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1528-2511
pubmed:author
pubmed:issnType
Print
pubmed:volume
258
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
140-9; discussion 149-59, 263-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Diversity of TRP channel activation.
pubmed:affiliation
KU Leuven, Department of Physiology, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't