Linked Life Data

15104174

Source:http://linkedlifedata.com/resource/pubmed/id/15104174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-4-23
pubmed:abstractText
TRPC genes encode a family of ion channel proteins that appear to be responsible for Ca2+ influx following stimulation of membrane receptors linked to phospholipase C. TRPC channels are thought to be tetrameric, and there is growing evidence to suggest heteromultimeric channel assembly. However, the channel subunit composition in vivo and the rules governing subunit assembly remain largely unknown. Like the Drosophila TRP channels, the mammalian TRPCs may reside in large signalling complexes localized to subcellular microdomains by interaction with specific PDZ-containing scaffolding proteins. Selective localization within cellular signalling networks may play an important role in the mode of channel activation following receptor stimulation. Evidence for heteromultimeric TRPC channel assembly gleaned from overexpression studies will be reviewed and recent evidence for the selective association of native TRPC channel subunits in rat brain will be discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1528-2511
pubmed:author
pubmed:issnType
Print
pubmed:volume
258
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-30; discussion 30-43, 98-102, 263-6
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Mammalian TRPC channel subunit assembly.
pubmed:affiliation
Rammelkamp Center for Education and Research, MetroHealth Medical Center, and the Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44109-1998, USA.
pubmed:publicationType
Journal Article, Review