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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-4-22
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pubmed:abstractText |
During natural infection with the agent of Lyme disease, Borrelia burgdorferi, spirochetes are delivered with vector saliva, which contains anti-inflammatory and antihemostatic activities. We show here that the saliva of ixodid ticks reduces polymorphonuclear leukocyte (PMN) adhesion via downregulation of beta2-integrins and decreases the efficiency of PMN in the uptake and killing of spirochetes. Inhibition of integrin adhesion and signaling reduces anti-inflammatory functions of PMN. These effects may favor the initial survival of spirochetes in vivo.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-10749868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-10886716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-11119556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-11254684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-11920297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-12085324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-12194906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-12537131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-12749013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-12874352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-1404261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-1527418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-15463328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-2157607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-2475511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-2783496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-2982989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-3038962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-8064226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-8394007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-8423346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-8575271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-8986723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-9326652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15102811-9353065
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2989-94
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15102811-Animals,
pubmed-meshheading:15102811-Bacterial Adhesion,
pubmed-meshheading:15102811-Borrelia burgdorferi,
pubmed-meshheading:15102811-Cell Size,
pubmed-meshheading:15102811-Chemotaxis, Leukocyte,
pubmed-meshheading:15102811-Cytotoxicity, Immunologic,
pubmed-meshheading:15102811-Humans,
pubmed-meshheading:15102811-Ixodes,
pubmed-meshheading:15102811-Lyme Disease,
pubmed-meshheading:15102811-Neutrophils,
pubmed-meshheading:15102811-Saliva
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pubmed:year |
2004
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pubmed:articleTitle |
Tick saliva reduces adherence and area of human neutrophils.
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pubmed:affiliation |
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA. ruth.montgomery@yale.edu
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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