| pubmed-article:15101725 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15101725 | lifeskim:mentions | umls-concept:C0026764 | lld:lifeskim |
| pubmed-article:15101725 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15101725 | lifeskim:mentions | umls-concept:C0206431 | lld:lifeskim |
| pubmed-article:15101725 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:15101725 | lifeskim:mentions | umls-concept:C0332152 | lld:lifeskim |
| pubmed-article:15101725 | lifeskim:mentions | umls-concept:C0439661 | lld:lifeskim |
| pubmed-article:15101725 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:15101725 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15101725 | pubmed:dateCreated | 2004-4-22 | lld:pubmed |
| pubmed-article:15101725 | pubmed:abstractText | Murine T cells do not endogenously upregulate CD80 expression but rather acquire CD80 from antigen presenting cells (APC) during CD28 ligation. Murine CD80+ memory T cells undergo apoptosis in the presence of high levels of antigen while naive CD80+ T cells are capable of acting as APC and T cell:T cell ligation induces anergy and unresponsiveness to antigen rechallenge. Reversing T cell unresponsiveness may be a key factor in the development of immunotherapy strategies for patients with myeloma. We have determined that B7+ T cells (CD80+ or CD86+) are common in patients with myeloma (n = 45), can be either CD4 or CD8, tend to be associated with stable disease and are polyclonal memory T cells (CD45RO). CD80 mRNA expression was present in CD80+ monocytes but not in CD3+ cells with a similar level of CD80 antigen expression. CD80 and CD86 antigen expression was upregulated on B cells but not T cells during incubation with trimeric human CD40 ligand (huCD40LT) + IL-2. Although there was a gradual loss of expression during in vitro culture, CD80+ T cells could be purified for further study. We conclude that B7 expression is common on T cells of patients with myeloma but that this is acquired rather than endogenously produced. B7+ CD45RO+ T cells constitute a population of memory T cells chronically exposed to antigen and warrant further study. | lld:pubmed |
| pubmed-article:15101725 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15101725 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15101725 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15101725 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15101725 | pubmed:issn | 1042-8194 | lld:pubmed |
| pubmed-article:15101725 | pubmed:author | pubmed-author:GibsonJohnJ | lld:pubmed |
| pubmed-article:15101725 | pubmed:author | pubmed-author:PopeBelindaB | lld:pubmed |
| pubmed-article:15101725 | pubmed:author | pubmed-author:BrownRossR | lld:pubmed |
| pubmed-article:15101725 | pubmed:author | pubmed-author:HoP JoyPJ | lld:pubmed |
| pubmed-article:15101725 | pubmed:author | pubmed-author:SzeDanielD | lld:pubmed |
| pubmed-article:15101725 | pubmed:author | pubmed-author:MurrayAllanA | lld:pubmed |
| pubmed-article:15101725 | pubmed:author | pubmed-author:JoshuaDougD | lld:pubmed |
| pubmed-article:15101725 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15101725 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:15101725 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15101725 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15101725 | pubmed:pagination | 363-71 | lld:pubmed |
| pubmed-article:15101725 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:15101725 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15101725 | pubmed:articleTitle | B7+ T cells in myeloma: an acquired marker of prior chronic antigen presentation. | lld:pubmed |
| pubmed-article:15101725 | pubmed:affiliation | Institute of Haematology, Royal Prince Alfred Hospital, Sydney, NSW Australia. rbrown@haem.rpa.cs.nsw.gov.au | lld:pubmed |
| pubmed-article:15101725 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15101725 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15101725 | lld:pubmed |
