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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2004-4-21
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pubmed:abstractText |
Lymphocyte activation gene-3 (LAG-3) is a CD4-related, activation-induced cell surface molecule that binds to MHC class II with high affinity. In this study, we used four experimental systems to reevaluate previous suggestions that LAG-3(-/-) mice had no T cell defect. First, LAG-3(-/-) T cells exhibited a delay in cell cycle arrest following in vivo stimulation with the superantigen staphylococcal enterotoxin B resulting in increased T cell expansion and splenomegaly. Second, increased T cell expansion was also observed in adoptive recipients of LAG-3(-/-) OT-II TCR transgenic T cells following in vivo Ag stimulation. Third, infection of LAG-3(-/-) mice with Sendai virus resulted in increased numbers of memory CD4(+) and CD8(+) T cells. Fourth, CD4(+) T cells exhibited a delayed expansion in LAG-3(-/-) mice infected with murine gammaherpesvirus. In summary, these data suggest that LAG-3 negatively regulates T cell expansion and controls the size of the memory T cell pool.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/CD223 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/enterotoxin B, staphylococcal
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5450-5
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pubmed:dateRevised |
2009-12-15
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pubmed:meshHeading |
pubmed-meshheading:15100286-Adoptive Transfer,
pubmed-meshheading:15100286-Animals,
pubmed-meshheading:15100286-Antigens, Bacterial,
pubmed-meshheading:15100286-Antigens, CD,
pubmed-meshheading:15100286-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15100286-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15100286-Cell Division,
pubmed-meshheading:15100286-Enterotoxins,
pubmed-meshheading:15100286-Gammaherpesvirinae,
pubmed-meshheading:15100286-Herpesviridae Infections,
pubmed-meshheading:15100286-Immunologic Memory,
pubmed-meshheading:15100286-Lymphocyte Activation,
pubmed-meshheading:15100286-Lymphocyte Count,
pubmed-meshheading:15100286-Mice,
pubmed-meshheading:15100286-Mice, Inbred C57BL,
pubmed-meshheading:15100286-Mice, Knockout,
pubmed-meshheading:15100286-Mice, Transgenic,
pubmed-meshheading:15100286-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:15100286-Respirovirus Infections,
pubmed-meshheading:15100286-Sendai virus,
pubmed-meshheading:15100286-Splenomegaly,
pubmed-meshheading:15100286-Staphylococcus aureus,
pubmed-meshheading:15100286-T-Lymphocyte Subsets
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pubmed:year |
2004
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pubmed:articleTitle |
Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo.
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pubmed:affiliation |
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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