Linked Life Data

15099630

Source:http://linkedlifedata.com/resource/pubmed/id/15099630

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pubmed-article:15099630pubmed:dateCreated2004-4-21lld:pubmed
pubmed-article:15099630pubmed:abstractTextTo comprehensively evaluate gene expression in the early stage of fracture healing, we used a cDNA microarray with 2304 cDNA clones derived from an oligo-capped mouse embryo library. Closed mid-diaphyseal fractures were created in mouse tibiae and expression profiles were analyzed 3 days after fracture. Six genes were up-regulated in comparison to those in unfractured bones and these included three genes previously identified but never shown to be present in fractures, periostin, calumenin, and FHL-1. Cloning of these genes has been completed but their expression pattern and function during fracture healing and bone formation remain to be elucidated. Up-regulation of the six genes was reconfirmed by semi-quantitative RT-PCR analysis. Spatial and temporal expression of one of the newly identified fracture-induced genes, periostin, was analyzed using in situ hybridization, because it displayed the highest up-regulation ratio. A signal for periostin was detected in undifferentiated mesenchymal cells and immature preosteoblastic cells in the periosteal tissues between days 3 and 14 after fracture. Northern analysis showed that periostin gene expression rapidly increased by day 3, reached a peak on day 7, and declined by day 14. These findings suggest that periostin is a specific marker for preosteoblasts and may play an important role in periosteal callus formation during the early stage of fracture healing.lld:pubmed
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pubmed-article:15099630pubmed:pagination520-5lld:pubmed
pubmed-article:15099630pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15099630pubmed:year2004lld:pubmed
pubmed-article:15099630pubmed:articleTitleGene expression of periostin in the early stage of fracture healing detected by cDNA microarray analysis.lld:pubmed
pubmed-article:15099630pubmed:affiliationDepartment of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan.lld:pubmed
pubmed-article:15099630pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15099630pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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