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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2004-5-4
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pubmed:abstractText |
The expression of certain genes involved in fundamental metabolism is regulated by metabolite-binding "riboswitch" elements embedded within their corresponding mRNAs. We have identified at least six additional elements within the Bacillus subtilis genome that exhibit characteristics of riboswitch function (glmS, gcvT, ydaO/yuaA, ykkC/yxkD, ykoK, and yybP/ykoY). These motifs exhibit extensive sequence and secondary-structure conservation among many bacterial species and occur upstream of related genes. The element located upstream of the glmS gene in Gram-positive organisms functions as a metabolite-dependent ribozyme that responds to glucosamine-6-phosphate. Other motifs form complex folded structures when transcribed as RNA molecules and carry intrinsic terminator structures. These findings indicate that riboswitches serve as a major genetic regulatory mechanism for the control of metabolic genes in many microbial species.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15096624-10213678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15096624-10230402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15096624-10529804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15096624-10573122,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15096624-12562800,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15096624-6469978
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
pubmed-author:BarrickJeffrey EJE,
pubmed-author:BreakerRonald RRR,
pubmed-author:CollinsJenniferJ,
pubmed-author:CorbinoKeith AKA,
pubmed-author:JonaInbalI,
pubmed-author:LeeMarkM,
pubmed-author:MandalMaumitaM,
pubmed-author:NahviAliA,
pubmed-author:RothAdamA,
pubmed-author:SudarsanNarasimhanN,
pubmed-author:WickiserJ KennethJK,
pubmed-author:WinklerWade CWC
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6421-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2004
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pubmed:articleTitle |
New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control.
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pubmed:affiliation |
Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208103, New Haven, CT 06520-8103, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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