Linked Life Data

15094349

Source:http://linkedlifedata.com/resource/pubmed/id/15094349

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-4-19
pubmed:abstractText
Gap junction channels provide the basis for intercellular communication and play an important physiological role in the cardiovascular system for maintenance of the normal cardiac rhythm, regulation of vascular tone, endothelial function and myoendothelial interaction as well as for metabolic interchange between the cells. Thus, pharmacological influence on these channels might help to elucidate their role in physiology and pathophysiology and might reveal new therapeutic approaches. The gap junction conductance between two cells is defined by the number of channels, the single channel conductance and the mean open and closed time. In principle, it is possible pharmacologically to induce closing of the channels, to change preferred single channel conductance, to open channels (or to keep them open), and to regulate the expression, synthesis, assembly and degradation of the channels thereby controlling the number of channels. This review describes the various substances affecting these parameters and outlines the possible pharmacological use of such drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0008-6363
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
287-98
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Pharmacology of gap junctions in the cardiovascular system.
pubmed:affiliation
Clinic for Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Struempellstr. 39, 04289 Leipzig, Germany. dhes@medizin.uni-leipzig.de
pubmed:publicationType
Journal Article, Review