Linked Life Data

15094130

Source:http://linkedlifedata.com/resource/pubmed/id/15094130

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-4-19
pubmed:abstractText
The brains of all vertebrates are persistently neurogenic. However, this is not true for the neural retinas. Only three extant classes of vertebrates show significant posthatch/postnatal retinal neurogenesis: amphibians, birds and fish. The retinas of these animals contain an annulus of progenitors at the margin, from which differentiated neurons emerge. In posthatch amphibians and fish the vast majority of the adult retina is added from the margin and neurogenesis is lifelong, whereas in posthatch birds neurogenesis is limited. Unique to fish, rod photoreceptors are added in situ from stem cells within the mature retina. Strikingly, for each class of animal retinal lesions stimulate neuronal regeneration, however the cellular source differs for each: the retinal pigmented epithelium in amphibians and embryonic birds, Müller glia in posthatch birds and intrinsic stem cells in fish. The molecular events surrounding injury-induced neuronal regeneration are beginning to be identified.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1350-9462
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-94
pubmed:dateRevised
2009-1-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Persistent and injury-induced neurogenesis in the vertebrate retina.
pubmed:affiliation
Department of Ophthalmology and Visual Sciences and The Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA. peterh@umich.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review