Linked Life Data

15093985

Source:http://linkedlifedata.com/resource/pubmed/id/15093985

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2004-4-19
pubmed:abstractText
We investigated the relationship between clinical, electrocardiographic and angiographic characteristics with development of refractory angina and acute myocardial infarction (AMI) in 976 consecutive patients with unstable angina (UA). AMI occurred in 63 (6%) and recurrent angina in 384 (39%), 201 of whom had >2 episodes (refractory, 21%). Patients with AMI were older (P<0.001) and had a higher rate of smoking (P<0.02), previous cerebrovascular accident (P<0.02), abnormal ST segment on admission (P<0.002), refractory angina (P<0.001) and multivessel disease (P<0.005) than those without AMI. Patients with refractory angina were older (P<0.001) and showed a higher incidence of abnormal ST segment on admission (P<0.001) and multivessel disease (P<0.001) than those without. A multivariate analysis, however, showed that refractory angina (P<0.0001), and multivessel disease (P<0.001) were the strongest predictors of AMI while age and multivessel disease were the strongest predictors of refractory angina (P<0.003). Thus, multivessel disease was the most frequent substrate of refractory angina and AMI in patients with UA. These findings may suggest that significant coronary stenosis in non-culprit arteries may facilitate recurrence of ischemia/AMI perhaps by reacting in concert with the culprit lesion and causing a further reduction of the ischemic threshold.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0167-5273
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Relevance of multivessel disease in the development of in-hospital refractory angina and myocardial infarction in patients with unstable angina.
pubmed:affiliation
Unitat Coronària, Servei de Cardiologia, Hospital General Vall d'Hebron, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain. 5751jfb@comb.es
pubmed:publicationType
Journal Article