| pubmed-article:15093750 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15093750 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:15093750 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:15093750 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15093750 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:15093750 | lifeskim:mentions | umls-concept:C0039341 | lld:lifeskim |
| pubmed-article:15093750 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15093750 | pubmed:dateCreated | 2004-4-19 | lld:pubmed |
| pubmed-article:15093750 | pubmed:abstractText | Patients infected with human immunodeficiency virus type 1 (HIV-1) develop a spectrum of B cell lymphoproliferative disorders ranging from polyclonal B cell activation to B cell lymphomas. While a direct role of Epstein-Barr virus (EBV) is well recognized for most of these lesions, recent findings have suggested that transactivator HIV-1 Tat protein might be involved in the pathogenesis of B cell lymphomas. Tat-expressing EBV-positive B cells were generated by transduction with a retroviral Tat-encoding vector. B(Tat+) cells expressed lower levels of anti-apoptotic protein Bcl-2 than parental and control B(Tat-) cells, generated by transduction with an empty retroviral vector, and were more prone to apoptosis upon serum withdrawal, as assessed by analysis of annexin V-stained cells and cleavage of poly-ADP-ribose-polymerase by caspase 3. Nevertheless, in serum starvation, B(Tat-) cells mainly exhibited the Rb hypo-phosphorylated form, underwent cell cycle arrest, and grew in single cell suspension, while B(Tat+) cells displayed the Rb hyper-phoshorylated form, progressed throughout the cell cycle, and retained the ability to grow in small clumps. Finding that B(Tat+) cells maintained proliferative capacity upon serum withdrawal suggests that cells expressing Tat have growth advantages among the EBV-driven cell proliferations and may originate B cell clones with more oncogenic potential. | lld:pubmed |
| pubmed-article:15093750 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15093750 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093750 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15093750 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15093750 | pubmed:month | May | lld:pubmed |
| pubmed-article:15093750 | pubmed:issn | 0014-4827 | lld:pubmed |
| pubmed-article:15093750 | pubmed:author | pubmed-author:BallonGiannaG | lld:pubmed |
| pubmed-article:15093750 | pubmed:author | pubmed-author:Chieco-Bianch... | lld:pubmed |
| pubmed-article:15093750 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:15093750 | pubmed:author | pubmed-author:TerrinLiliana... | lld:pubmed |
| pubmed-article:15093750 | pubmed:author | pubmed-author:RossiElisabet... | lld:pubmed |
| pubmed-article:15093750 | pubmed:author | pubmed-author:IndraccoloSte... | lld:pubmed |
| pubmed-article:15093750 | pubmed:author | pubmed-author:ColombrinoEva... | lld:pubmed |
| pubmed-article:15093750 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15093750 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15093750 | pubmed:volume | 295 | lld:pubmed |
| pubmed-article:15093750 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15093750 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15093750 | pubmed:pagination | 539-48 | lld:pubmed |
| pubmed-article:15093750 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15093750 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15093750 | pubmed:articleTitle | Human immunodeficiency virus type 1 Tat protein modulates cell cycle and apoptosis in Epstein-Barr virus-immortalized B cells. | lld:pubmed |
| pubmed-article:15093750 | pubmed:affiliation | Department of Oncology and Surgical Sciences, Section of Oncology, University of Padova, Padua, Italy. | lld:pubmed |
| pubmed-article:15093750 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15093750 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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