| pubmed-article:15093542 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15093542 | lifeskim:mentions | umls-concept:C0206180 | lld:lifeskim |
| pubmed-article:15093542 | lifeskim:mentions | umls-concept:C0054950 | lld:lifeskim |
| pubmed-article:15093542 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:15093542 | lifeskim:mentions | umls-concept:C0029005 | lld:lifeskim |
| pubmed-article:15093542 | lifeskim:mentions | umls-concept:C1456796 | lld:lifeskim |
| pubmed-article:15093542 | lifeskim:mentions | umls-concept:C1705984 | lld:lifeskim |
| pubmed-article:15093542 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:15093542 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:15093542 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15093542 | pubmed:dateCreated | 2004-4-19 | lld:pubmed |
| pubmed-article:15093542 | pubmed:abstractText | NPM-ALK characterizes anaplastic large cell lymphoma (ALCL), as does the high expression of CD30, a feature shared with H-RS cells of classic Hodgkin's lymphoma. In H-RS cells, ligand-independent signaling by overexpressed CD30 drives constitutive NF-kappaB activation, which is absent in ALCL cells. Here we show that NPM-ALK impedes CD30 signaling and NF-kappaB activation, dependent on both ALK kinase activity and the N-terminal NPM domain. NPM-ALK transduction into H-RS cell lines abrogates recruitment and aggregation of TRAF proteins, inducing an ALCL-like morphology and phenotype. TRAF2 associates with NPM-ALK at a consensus binding motif located in the kinase domain. Thus, NPM-ALK abrogates CD30-driven NF-kappaB activation and can also induce an ALCL phenotype, distinguishing ALCL cells from H-RS cells of T cell origin. | lld:pubmed |
| pubmed-article:15093542 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093542 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15093542 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093542 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15093542 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093542 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093542 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093542 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093542 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093542 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093542 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093542 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093542 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093542 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15093542 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15093542 | pubmed:issn | 1535-6108 | lld:pubmed |
| pubmed-article:15093542 | pubmed:author | pubmed-author:WatanabeToshi... | lld:pubmed |
| pubmed-article:15093542 | pubmed:author | pubmed-author:HorieRyouichi... | lld:pubmed |
| pubmed-article:15093542 | pubmed:author | pubmed-author:IshidaTakaomi... | lld:pubmed |
| pubmed-article:15093542 | pubmed:author | pubmed-author:HigashiharaMa... | lld:pubmed |
| pubmed-article:15093542 | pubmed:author | pubmed-author:KadinMarshall... | lld:pubmed |
| pubmed-article:15093542 | pubmed:author | pubmed-author:WatanabeMarik... | lld:pubmed |
| pubmed-article:15093542 | pubmed:author | pubmed-author:KoiwaTsukasaT | lld:pubmed |
| pubmed-article:15093542 | pubmed:author | pubmed-author:AizawaShigemi... | lld:pubmed |
| pubmed-article:15093542 | pubmed:author | pubmed-author:ItohKinjiK | lld:pubmed |
| pubmed-article:15093542 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15093542 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:15093542 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15093542 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15093542 | pubmed:pagination | 353-64 | lld:pubmed |
| pubmed-article:15093542 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:meshHeading | pubmed-meshheading:15093542... | lld:pubmed |
| pubmed-article:15093542 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15093542 | pubmed:articleTitle | The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-kappaB activation in anaplastic large cell lymphoma. | lld:pubmed |
| pubmed-article:15093542 | pubmed:affiliation | Fourth Department of Internal Medicine, Faculty of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan. | lld:pubmed |
| pubmed-article:15093542 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15093542 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15093542 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15093542 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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