| pubmed-article:15093181 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15093181 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15093181 | lifeskim:mentions | umls-concept:C0684249 | lld:lifeskim |
| pubmed-article:15093181 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:15093181 | lifeskim:mentions | umls-concept:C0574895 | lld:lifeskim |
| pubmed-article:15093181 | lifeskim:mentions | umls-concept:C2699153 | lld:lifeskim |
| pubmed-article:15093181 | lifeskim:mentions | umls-concept:C1269955 | lld:lifeskim |
| pubmed-article:15093181 | lifeskim:mentions | umls-concept:C1366521 | lld:lifeskim |
| pubmed-article:15093181 | lifeskim:mentions | umls-concept:C1149234 | lld:lifeskim |
| pubmed-article:15093181 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:15093181 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:15093181 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15093181 | pubmed:dateCreated | 2004-4-19 | lld:pubmed |
| pubmed-article:15093181 | pubmed:abstractText | We have previously observed the suppression of lung tumor growth in response to overexpression of melanoma differentiation-associated gene-7 (MDA-7)/interleukin-24 (IL-24; approved gene symbol IL24) in vitro and in vivo. MDA-7/IL-24 exerts its tumor-suppressive effects by multiple mechanisms, including the activation of the caspase cascade and the inhibition of angiogenesis. In this study, we used an adenoviral vector (Ad-mda7) to examine the effect of the ectopic production of MDA-7/IL-24 on cell migration and invasion by human non-small-cell lung carcinoma cells. Lung tumor cells (H1299 and A549) treated in vitro with Ad-mda7 migrated and invaded less than cells treated with phosphate-buffered saline (PBS) or Ad-Luc (vector control). MDA-7/IL-24 inhibited migration and invasion by down-regulating the production of phosphatidylinositol 3-kinase/protein kinase B, focal adhesion kinase, and matrix metalloproteinase-2 and -9 relative to PBS and Ad-Luc. Furthermore, tumor cells treated with Ad-mda7 ex vivo or with DOTAP:Chol-mda7 complex in vivo formed significantly fewer tumors in an experimental lung metastasis model. These results show that MDA-7/IL-24 inhibits invasion and migration by lung cancer cells by down-regulating proteins associated with these processes, resulting in reduced metastasis. Thus, Ad-mda7 should be considered a therapeutic agent that can inhibit primary tumor growth and prevent metastasis. | lld:pubmed |
| pubmed-article:15093181 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15093181 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15093181 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15093181 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15093181 | pubmed:issn | 1525-0016 | lld:pubmed |
| pubmed-article:15093181 | pubmed:author | pubmed-author:ChadaSunilS | lld:pubmed |
| pubmed-article:15093181 | pubmed:author | pubmed-author:SaitoYujiY | lld:pubmed |
| pubmed-article:15093181 | pubmed:author | pubmed-author:MhashilkarAbn... | lld:pubmed |
| pubmed-article:15093181 | pubmed:author | pubmed-author:KIDDA AAA | lld:pubmed |
| pubmed-article:15093181 | pubmed:author | pubmed-author:RameshRajagop... | lld:pubmed |
| pubmed-article:15093181 | pubmed:author | pubmed-author:BeganGopalanG | lld:pubmed |
| pubmed-article:15093181 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15093181 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:15093181 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15093181 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15093181 | pubmed:pagination | 510-8 | lld:pubmed |
| pubmed-article:15093181 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15093181 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15093181 | pubmed:articleTitle | Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells. | lld:pubmed |
| pubmed-article:15093181 | pubmed:affiliation | Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. rramesh@mdanderson.org | lld:pubmed |
| pubmed-article:15093181 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15093181 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15093181 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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