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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-4-19
pubmed:abstractText
Aortic pulse wave velocity (PWV) is a predictor of atherosclerosis. The percent mean pulse amplitude of the artery (%MPA) has been proposed as a novel marker of atherosclerosis. The present study evaluated the predictive value of PWV and the %MPA for coronary atherosclerosis. The severity of coronary atherosclerosis was evaluated using both the Gensini score and coronary calcium grade. Thirty-three patients with cardiovascular risk factors were assigned to those with significant coronary artery stenosis ((+)stenosis) group with the presence of > or = 75% coronary artery stenosis (n = 15; age: 68 +/- 7 years, mean +/- SD) or those without significant coronary artery stenosis ((-)stenosis) group (n = 18; age: 66 +/- 8 years). In each patient, the PWV and %MPA at the right brachial artery and both sides of the ankle were obtained using a non-invasive vascular screening device. The Gensini score and coronary calcium grade were higher in the +stenosis group than they were in the (-)stenosis group (P < 0.01 and P < 0.05, respectively). The brachial %MPA was lower in the (+)stenosis group than it was in the -stenosis group (P < 0.005). Both the Gensini score and the coronary calcium grade correlated with the brachial %MPA (r = 0.62, P = 0.0001 and P = 0.33, P = 0.030, respectively). Our observations suggest that brachial %MPA provides predictive values for coronary atherosclerosis in subjects at risk for cardiovascular disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-4868
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
231-42
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15090699-Aged, pubmed-meshheading:15090699-Blood Flow Velocity, pubmed-meshheading:15090699-Brachial Artery, pubmed-meshheading:15090699-Calcinosis, pubmed-meshheading:15090699-Cardiovascular Diseases, pubmed-meshheading:15090699-Coronary Angiography, pubmed-meshheading:15090699-Coronary Artery Disease, pubmed-meshheading:15090699-Coronary Disease, pubmed-meshheading:15090699-Coronary Stenosis, pubmed-meshheading:15090699-Female, pubmed-meshheading:15090699-Humans, pubmed-meshheading:15090699-Male, pubmed-meshheading:15090699-Middle Aged, pubmed-meshheading:15090699-Predictive Value of Tests, pubmed-meshheading:15090699-Pulse, pubmed-meshheading:15090699-Risk Factors, pubmed-meshheading:15090699-Severity of Illness Index, pubmed-meshheading:15090699-Tomography, Spiral Computed
pubmed:year
2004
pubmed:articleTitle
Brachial arterial stiffness predicts coronary atherosclerosis in patients at risk for cardiovascular diseases.
pubmed:affiliation
Department of Internal Medicine I, School of Medicine, Oita Medical University, Oita, Japan.
pubmed:publicationType
Journal Article