Source:http://linkedlifedata.com/resource/pubmed/id/15090268
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
2004-4-19
|
pubmed:abstractText |
beta-amyloid (Abeta) is the main constituent of senile plaques seen in Alzheimer's disease. Abeta is derived from the amyloid precursor protein (APP) via proteolytic cleavage by proteases beta- and gamma-secretase. In this study, we examined content and localization of beta-secretase-cleaved APP (beta-sAPP) in brain tissue sections from the frontal, temporal and occipital lobe. Strong granular beta-sAPP staining was found throughout the gray matter of all three areas, while white matter staining was considerably weaker. beta-sAPP was found to be localized in astrocytes and in axons. We found the beta-sAPP immunostaining to be stronger and more extensive in gray matter in Alzheimer disease (AD) cases than controls. The axonal beta-sAPP staining was patchy and unevenly distributed for the AD cases, indicating impaired axonal transport. beta-sAPP was also found surrounding senile plaques and cerebral blood vessels. The results presented here show altered beta-sAPP staining in the AD brain, suggestive of abnormal processing and transport of APP.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid Precursor Protein Secretases,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Protein Precursor,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/BACE1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Endopeptidases
|
pubmed:status |
MEDLINE
|
pubmed:issn |
1582-1838
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
8
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
127-34
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:15090268-Alzheimer Disease,
pubmed-meshheading:15090268-Amyloid Precursor Protein Secretases,
pubmed-meshheading:15090268-Amyloid beta-Protein Precursor,
pubmed-meshheading:15090268-Aspartic Acid Endopeptidases,
pubmed-meshheading:15090268-Astrocytes,
pubmed-meshheading:15090268-Axons,
pubmed-meshheading:15090268-Brain,
pubmed-meshheading:15090268-Endopeptidases,
pubmed-meshheading:15090268-Humans,
pubmed-meshheading:15090268-Immunohistochemistry,
pubmed-meshheading:15090268-Microscopy, Fluorescence
|
pubmed:articleTitle |
Beta-secretase-cleaved amyloid precursor protein in Alzheimer brain: a morphologic study.
|
pubmed:affiliation |
Karolinska Institutet, Neurotec, Section of Experimental Geriatrics, KFC Novum, Huddinge, S-141 86, Sweden.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|