Linked Life Data

15090229

Source:http://linkedlifedata.com/resource/pubmed/id/15090229

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-4-19
pubmed:abstractText
Nuclear hormone receptors (NHRs) represent one of the most important drug targets in terms of therapeutic applications. The NHR superfamily consists of a family of DNA binding transcription factors whose function can be controlled by small molecules (steroids or organic acids). Therefore, NHRs are suitable protein targets for the therapies of human diseases. Some of the current marketed drugs, including several anticancer and antidiabetic drugs, are known to target NHRs. Examples include the anticancer and retinoid X receptor-targeting Targretin and the antidiabetic and peroxisome proliferative-activated receptor-gamma-targeting thiaozolidinediones. More NHR-targeting drugs are expected in the coming years. Identification of specific NHR modulators, as well as identification of ligands for orphan NHRs, will lead to new therapies for many human diseases. Many pharmaceutical companies are investing in NHR-targeted drugs, which are estimated to be 10-15% of the US dollars 400 billion global pharmaceutical market. This minireview discusses various aspects of NHR drug discovery, with a focus on the application of NHR coactivators in assay design for NHR ligand identification.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1540-658X
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
835-42
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Coactivators in assay design for nuclear hormone receptor drug discovery.
pubmed:affiliation
Lead Discovery and Profiling, Bristol-Myers Squibb Company, Wallingford, CT 06492, USA. taosheng.chen@bms.com
pubmed:publicationType
Journal Article, Review