15088033

Source:http://linkedlifedata.com/resource/pubmed/id/15088033

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0018133, umls-concept:C0162638, umls-concept:C0205210, umls-concept:C0442027
pubmed:issue	4
pubmed:dateCreated	2004-4-16
pubmed:abstractText	Graft-versus-host disease (GVHD) is an untoward complication of bone marrow transplantation. It is characterized by an immune-mediated attack by donor immune cells against various host cells and tissues, a process which may be associated with significant morbidity in affected patients. Oral lesions are a common sequelae and can serve as a highly predictive index to the presence of systemic GVHD. The oral lesions of GVHD are clinically and histologically lichenoid in nature and can be a challenge in terms of management. Ulcerated and painful mucosal lesions may represent a significant impediment to normal eating habits and nutritional intake, necessitating appropriate diagnosis and treatment. Importantly, recent evidence has indicated that programmed cell death, or apoptosis, is the major constituent in the pathogenesis of GVHD. Apoptosis not only plays a major role in normal growth and ontogeny, but has been shown to contribute to a wide spectrum of both inflammatory and neoplastic disorders. Since knowledge of apoptotic molecular pathways is requisite for understanding GVHD, the purpose of this paper is to provide a fundamental overview of the predominant apoptotic mechanisms implicated in the pathogenesis of GVHD and to relate these findings to the oral complications of the disease. Finally, we will discuss management strategies for diagnosing and treating the oral lesions of GVHD. By explicating the molecular events in the apoptotic pathway, unique therapeutic and pharmacologic strategies for regulating apoptosis may be developed in the future, reducing the morbidity associated with conditions like GVHD.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9508562
pubmed:citationSubset	D
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	1079-2104
pubmed:author	pubmed-author:AllenCarl MCM, pubmed-author:AndersonKaren EKE, pubmed-author:DrakeA HAH, pubmed-author:KalmarJohn RJR, pubmed-author:LangJames CJC, pubmed-author:SedghizadehParish PPP
pubmed:issnType	Print
pubmed:volume	97
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	491-8
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:15088033-Apoptosis, pubmed-meshheading:15088033-Bone Marrow Transplantation, pubmed-meshheading:15088033-Graft vs Host Disease, pubmed-meshheading:15088033-Humans, pubmed-meshheading:15088033-Mouth Diseases, pubmed-meshheading:15088033-T-Lymphocytes, Cytotoxic
pubmed:year	2004
pubmed:articleTitle	Oral graft-versus-host disease and programmed cell death: pathogenetic and clinical correlates.
pubmed:affiliation	The Ohio State University College of Dentistry, Columbus 43218, USA. sedghizadeh.1@osu.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't